Evaluation of the biliary and brain distribution of technetium Tc 99m sestamibi in healthy dogs with the ABCB1 wildtype genotype before and after treatment with spinosad.

Objective: To determine whether the reported drug-drug interaction between the flea medication spinosad and ivermectin is attributable to inhibition of P-glycoprotein by spinosad.

Animals: 6 healthy adult dogs with the ABCB1 wildtype genotype.

Procedures: The study was conducted as a prospective, masked, randomized crossover design.