Publications by authors named "Trevor N Hawkins"
Background: HIV-associated diarrhea remains a significant concern with limited treatment options.
Objective: To determine the optimal dose, efficacy, and safety of crofelemer for noninfectious diarrhea.
Methods: This randomized, double-blind, phase 3 trial used a 2-stage design.
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Science
December 2010
Article Synopsis
- Researchers conducted a genome-wide association study focusing on HIV-1 controllers and progressors to understand genetic factors influencing chronic viral infections.
- They discovered over 300 significant single-nucleotide polymorphisms (SNPs) specifically within the major histocompatibility complex (MHC), emphasizing its importance for infectious diseases.
- Key findings indicate that specific amino acids in HLA proteins, especially HLA-B and HLA-C, significantly influence the interaction between HLA and viral peptides, affecting the control of HIV infection.