Publications by authors named "Trevor McGoldrick"
The deregulation of monounsaturated, polyunsaturated, and saturated fatty acids (MUFAs, PUFAs, SFAs) from de novo synthesis and hypoxia are central metabolic features of breast tumour. Early response markers for neoadjuvant chemotherapy (NACT) are critical for stratified treatment for patients with breast cancer, and restoration of lipid metabolism and normoxia might precede observable structural change. In this study, we hypothesised that peri-tumoural lipid composition and hypoxia might be predictive and early response markers in patients with breast cancer undergoing NACT.
View Article and Find Full Text PDFIntroduction: The early identification of good responders to neoadjuvant chemotherapy (NACT) holds a significant potential in the optimal treatment of breast cancer. A recent Bayesian approach has been postulated to improve the accuracy of the intravoxel incoherent motion (IVIM) model for clinical translation. This study examined the prediction and early sensitivity of Bayesian IVIM to NACT response.
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- - Male breast cancer (MBC) is a rare condition, making up less than 1% of all breast cancers, yet it is often treated with the same strategies as female breast cancer (FBC), despite key differences.
- - Significant mutations in DNA damage response genes are linked to MBC development, but advancements in treatment are lagging compared to progress seen in FBC and other cancers.
- - The review calls for increased collaboration and research to improve MBC treatment outcomes and explores promising developments, like PARP inhibitors, that have benefitted FBC and prostate cancer.
Article Synopsis
- The study investigates the presence and impact of structural variations (SVs) at the BRCA1/2 genes in high-grade serous ovarian carcinoma, emphasizing their contribution to homologous recombination repair deficiency (HRD).
- Using whole-genome and RNA sequencing data from 205 tumors, researchers identified significant occurrences of large deletions in addition to known short somatic mutations (SSMs).
- The findings reveal that SVs, often overlooked, significantly affect patient outcomes and suggest that recognizing these variations can enhance patient selection for HRD-targeted therapies.
Lipid composition in breast cancer, a central marker of disease progression, can be non-invasively quantified using 2D MRS method of double quantum filtered correlation spectroscopy (DQF-COSY). The low signal to noise ratio (SNR), arising from signal retention of only 25% and depleted lipids within tumour, demands improvement approaches beyond signal averaging for clinically viable applications. We therefore adapted and examined combination algorithms, designed for 1D MRS, for 2D MRS with both internal and external references.
View Article and Find Full Text PDFWe present a case of cardiac ischaemia associated with capecitabine chemotherapy. An elderly female receiving capecitabine chemotherapy developed acute onset severe anterior chest pain associated with ischaemic changes on ECG. The pain and ECG changes failed to respond to thrombolysis and she proceeded to coronary angiogram and stenting of a thrombosed right coronary vessel.
View Article and Find Full Text PDFProximal tubular cells from human (HPT) and rat (RPT) kidneys were isolated, grown to confluence and incubated with S-(1,2-dichlorovinyl)- l-cysteine (DCVC), S-(1,2,2-trichlorovinyl)- l-cysteine (TCVC), S-(1,1,2,2-tetrafluoroethyl)- l-cysteine (TFEC) and S-(2-chloro-1,1-difluorethyl)- l-cysteine (CDFEC), the cysteine conjugates of nephrotoxicants. The cultures were exposed to the conjugates for 12, 24 and 48 h and the toxicity determined using the MTT assay. All four conjugates caused dose-dependent toxicity to RPT cells over the range 50-1,000 microM, the order of toxicity being DCVC>TCVC>TFEC=CDFEC.
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