Publications by authors named "Trevor J Wolfe"
Phosphoinositide (PIP) signaling plays pivotal roles in myriad biological processes and is altered in many diseases including cancer. Canonical PIP signaling involves membrane-associated PIP lipid second messengers that modulate protein recruitment and activity at membrane focal points. In the nucleus, PIP signaling operates separately from membranous compartments defining the paradigm of non-canonical PIP signaling.
View Article and Find Full Text PDFA study of major cannabinoids via Raman spectroscopy and density functional theory.
Spectrochim Acta A Mol Biomol Spectrosc
December 2023
Article Synopsis
- Cannabinoids are important molecules from the cannabis plant that are being extensively studied due to their varied legal status and usage.
- This research presents Raman spectra for eleven cannabinoids, comparing real experimental data to theoretical simulations, including acids and neutral forms of cannabinoids.
- While the experimental data showed greater peak separation than simulated results, differences were noted in the -OH stretching region, indicating its potential use for studying decarboxylation reactions in cannabinoids.
Unlabelled: Phosphoinositide (PIP ) messengers are present in non-membranous regions of nuclei, where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that is distinct from the cytosolic membrane-localized pathway. In the nuclear pathway, PI kinases/phosphatases bind the p53 tumor suppressor protein (wild-type and mutant) to generate p53-PIP complexes that regulate Akt activation. However, this pathway is dependent on poorly characterized nuclear PIP pools.
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