Publications by authors named "Trevor Hughes"

Purpose: To report treatment outcomes of ab interno canaloplasty using the Visco360 and Omni system devices as a standalone procedure or combined with cataract surgery in patients with open-angle glaucoma (OAG).

Design: Retrospective, single-center, consecutive case series.

Study Patients: Eighty-nine eyes of 64 patients aged 43 to 91 with open-angle glaucoma treated with ab interno canaloplasty between January 2018 and September 2019.

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Mentorship of student nurses within the clinical environment is a well-established aspect of nurse training. With theory and practice being given equal weighting in the assessment of students' fitness to practise, effective mentorship in clinical settings is essential. While there have been calls for improvements to the clinical learning environment, the demands of daily practice mean it can be difficult to achieve effective mentorship.

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We have demonstrated capture and release of underwater-oil droplets based on fouling-resistant surfaces coated with pH-responsive polymer brushes. In response to the change of environmental pH, oil droplets were captured on the polymer brush-modified surfaces in the high adhesion state. As the droplet volume increased upon coalescence with other oil droplets in the aqueous phase, the captured droplets eventually self-released from the surfaces under the influence of buoyancy and rose to the air-water interface.

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Myasthenia gravis was first recognised as a distinct clinical entity by Thomas Willis, a 17th century Oxford physician, whose 1672 account in Latin was largely unnoticed until 1903. The first modern description was made in 1877 by Samuel Wilks, a London physician. Towards the close of the 19th century, primary muscle diseases and diseases due to denervation of muscle were studied by English, French, and German physicians.

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Flow-SANS experiments were performed on viscoelastic aqueous solutions of erucyl bis(hydroxyethyl) methylammonium chloride in the presence of potassium chloride. This cationic surfactant has the ability to form very long and flexible wormlike micelles upon addition of salt. The effects of the key-parameters-shear rate, temperature, surfactant and salt concentration-on the ability of the micelles to align in the flow-field were investigated.

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Small-angle neutron scattering studies were used to investigate the effect of adding an alcohol ethoxylate nonionic surfactant (d-C12E20) to aqueous solutions of a cationic surfactant, erucyl bis(hydroxyethyl) methylammonium chloride (EHAC), with and without salt (KCl). The systematic use of contrast-matching, by alternately highlighting or hiding one of the surfactants, confirms that mixed micelles are formed. In salt-free solutions, mixed spherical micelles are formed and a core-shell model combined with a Hayter-Penfold potential was used to describe the data.

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The structural and dynamic properties of micellar solutions of erucyl bis(hydroxyethyl)methylammonium chloride blended with 2-propanol, in the presence of KCl, have been investigated by means of light scattering and rheological experiments. In the dilute regime, the micellar growth is larger than expected from mean-field or scaling models. The results obtained in the vicinity of the overlap concentration suggest the presence of large aggregates, with size >100 nm, possibly micellar rings or microgels.

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The effect of adding an alcohol ethoxylate nonionic surfactant (C(18)E(18)) to aqueous solutions of a cationic surfactant, erucyl bis(hydroxyethyl) methylammonium chloride (EHAC,CH(3)(CH(2))(7)(CH)(2)(CH(2))(12)N(+)-(CH(2)CH(2)OH)(2)CH(3)Cl(-)), was studied using small-angle neutron scattering (SANS), steady-state rheology, and cryo-transmission electron microscopy (Cryo-TEM). This cationic surfactant has the ability to self-assemble into giant wormlike micelles in the presence of an electrolyte, such as KCl. In salt-free solutions, the mixture of the two surfactants gave rise to spherical micelles.

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