Publications by authors named "Trevor C Huang"
The healing effects of autologous platelet gel on acute human skin wounds.
Arch Facial Plast Surg
July 2007
Objective: To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers.
Methods: A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh.
Article Synopsis
- The adhesion of platelets at vascular injury sites is influenced by fluid shear stress, which can affect the behavior of specific integrin beta(3) variations.
- In experiments using different cell types, shear force was found to increase the adhesion of cells expressing the Pro33 form of integrin beta(3) more than the Leu33 form.
- This stronger adhesion under shear stress was sensitive to aspirin and was noted with certain proteins like fibrinogen and von Willebrand factor, but not with fibronectin.