[Induced acute non-lymphoblastic leukemia and prognostic significance of cytogenetic abnormalities: trisomy in chromosome 8, inv(16)(p13q22), and t(8;21)(q22;q22)].

3 patients with secondary acute non-lymphoblastic leucosis have been observed. The cytogenetic analysis revealed pathologic karyotypes: 46, XY,+8, t(8;21), inv 16. Two patients have been found with typical markers of damaged chromosome of radiation origion.

[P-glycoprotein expression in radiation-associated acute myeloid leukemia].

The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P<0,05).

[Endogenous intoxication, immunological reactivity and erythrocyte membrane permeability in patients with chronic myelogenous leukemia].

Patients with chronic myeloid leukemia (CML) have been shown to present with apparent metabolic abnormalities, such as enhanced endogenous intoxication against the background of deterioration of the functional condition of the liver and decline in immune reactivity of the organism; the erythrocytic membrane permeability changes considerably. The data secured are discussed from the standpoint of using them as prognostic criteria of the course of CML.

Hemoglobin-induced lipid peroxidation in anemia.

Changes were studied in processes of peroxide oxidation of lipid (LPO), such as neutral lipids and phospholipids, as related to the levels of hemoglobin (Hb) and its derivatives, methemoglobin (Met-Hb) and carboxyhemoglobin (CO-Hb) in erythrocytes and blood plasma of 33 patients with iron-deficiency anemia (IDA). It has been found out that in IDA, decline in the concentration of Hb correlates with augmentation of the content of Met-Hb (r = -0.670, P = 0.

[The use of Ukrainian laferon in the combined treatment of patients with chronic myeloid leukemia].

A study was made into the effect of laferon on effectiveness of treatment of patients with chronic myeloid leukemia (CML). The authors have reached the conclusion that drug tolerance in the patients is fairly good. The number of negative reactions within a few days of the start of laferon therapy did not exceed the level reported from other countries.

[The immunophenotypic and cytogenetic characteristics of the blast cells in subvariants of acute myeloid leukemia].

The results of study of morpho-cytochemical peculiarities, antigenic profile and peripheric blood and/or bone marrow blast cell karyotype of 21 patients with acute myeloid leukemia are presented. Hemopoietic cell immunophenotyping was carried out with the use of cytofluorometer FACScan and chromosome cytogenetic analysis with the use of analyzer "Metascan". It has been shown that in the AML M1 blast cell plasmatic membrane carries pan-myeloid CD33 and CD13 antigens, the last having high density of expression, and the CD38 antigen, which is a myeloid cell-precursor marker.

[The efficacy of active specific immunotherapy using modified neoplastic cells in the combined modality treatment of hemoblastoses].

Efficiency was studied of active specific immunotherapy (IT) with cell vaccine consisting of allogenic viable cryopreserved modified Con A blast cells identical with the illness in patients with acute myeloblastic leukemia and acute lymphoblastic leukemia. The studies made confirmed a positive impact of IT on the clinical course of acute leukosis (prolonged remission, keeping down infectious complications), on leukopoiesis, peripheral blood cells enzymatic status as well as on cell immunity, certain factors of humoral immunity and bodily natural antineoplastic resistance.

[The molecular biology diagnosis of neoplastic blood diseases].

Molecular-biological approaches was applied for detection of Philadelphia chromosome in patients with chronic myeloid and acute lymphoblastic leukemias. It includes bcr-genomic probes and polymerase chain reaction with specific bcr/abl primers. The latter is more preferable for clinic use.

[The efficacy of using thymalin and plasmapheresis in the combined treatment of patients with chronic lympholeukemia].

Results are submitted of study of the effectiveness of inclusion into the treatment program for patients with chronic lymphoid leukemia of specific (thymalin) and unspecific (plasmapheresis) means and modes of immune correction, which made for more rapid attaining clinical and hematological compensation by comparison with chemotherapeutic agents only. Furthermore, the method of combined use of drugs, attempted for the first time, permitted the functional activity of the lymphoid system to be improved, with the clinical and hematological compensation being achieved in a shorter space of time.

[The clinico-morphological characteristics of myeloid leukemias under the current ecological conditions in Ukraine].

Results are submitted of examination of 93 bone marrow trepanobiopsies from iliac bone of patients with acute and chronic leukemia they developed during 1993-1996. Some aspects are considered of haemopoiesis and stromal elements together with morphological features of the medical problem in question in present-day environmental health-hazard conditions. With AML and CML running aggressive course, the incidence rates of granulocytic and megakaryocytic CML being on the increase, the outlook for tomorrow is not bright.

[The criteria for forming risk groups among the population exposed to ionizing radiation after the accident at the Chernobyl Atomic Electric Power Station].

Studied were particular features of peripheral blood, certain immunological and biochemical indices under long-term exposure of human body to radiation after the accident at the Chernobyl Nuclear Power Plant. The study comprised 5578 individuals. The examinees were liquidators of the Chernobyl accident sequels (n = 1052), inhabitants of Pripyat evacuated from the town (n = 850), the Kiev SSBT primary donors (n = 1738).

[The results of studies of the peripheral blood from children in Polesie District, Kiev Province and in the city of Kiev 4 years after the accident at the Chernobyl Atomic Electric Power Station].

The peripheral blood of 2200 children (age: from 2 to 16 years) inhabiting the Polessye District of Kiev Province and the city of Kiev 4 years after the Chernobyl atomic station accident was studied. An analysis of results revealed the presence of hematologic changes that may be interpreted as sequels of the effect of ionizing radiation on the body, while other changes may be considered as reactive and may in most cases accompany different somatic diseases of infectious-inflammatory character.

[A hygienic basis for dosing the injection of coal flotation wastes into the soil as a fertilizer].

Hygienic regulations for the use of coal flotation wastes (CFW) as fertilizers were substantiated by studying the laws of migration of harmful ingredients of CFW from the fertilized soil to the contacting media. The safe doze of CFW to be used as a fertilizer was determined to be 3 g per 1 kg of soil (10 t/ha).

[The hormone level of patients with peptic ulcer being treated with L-dopa].

The basal level of adaptative hormones was assessed by means of the radioimmunological method in 80 patients with uncomplicated duodenal ulcer: in 40 of them before and after traditional treatment in the remaining 40 patients before and after L-DOPA treatment. It was found that employment of L-DOPA in patients with duodenal ulcer produces a positive effect, changes the hormonal picture, favorably influences ulcer epithelialization.