Case Report: Loss-of-Function Genetic Variant Associated With Ventricular Fibrillation.

Genetic variants in the gene, encoding the SUR2 auxiliary subunit from K channels, were previously linked with various inherited diseases. This wide range of congenital disorders includes multisystem and cardiovascular pathologies. The gain-of-function mutations result in Cantu syndrome, acromegaloid facial appearance, hypertrichosis, and acromegaloid facial features.

Combination of lead-field theory with cardiac vector direction: ECG imaging of septal ventricular activation.

Background: Despite the tremendous progress recently reported in ECG imaging (ECGI), some fundamental challenges are still hindering this non-invasive technology from meeting rising clinical expectations. In the present work, we address one of the major ECGI shortcomings in reconstruction of ventricular activation - the limited accuracy of endocardial and particularly septal mapping.

Methods: Ten CRT patients (five female, median (min-max) age - 61 (27-78) years) with previously implanted CRT devices underwent ECGI with isolated right ventricular (RV) pacing.

[Automatic detection of ventricular and supraventricular wide QRS arrhythmias using complex of morphological criteria and algorithms].

Aim: The aim of study is a detection of ventricular and supraventricular wide QRS arrhythmias using complex of morphological criteria and algorithms by method of automatic analysis.

Materials And Methods: For 100 patients (m/f - 61/39, Me (min; max) - 44.5 (10; 85) years) of researched group the analysis of 14306 single wide ectopic complexes (QRS 120-230 ms) has been done.

ECG Adapted Fastest Route Algorithm to Localize the Ectopic Excitation Origin in CRT Patients.

Although model-based solution strategies for the ECGI were reported to deliver promising clinical results, they strongly rely on some a priori assumptions, which do not hold true for many pathological cases. The fastest route algorithm (FRA) is a well-established method for noninvasive imaging of ectopic activities. It generates test activation sequences on the heart and compares the corresponding test body surface potential maps (BSPMs) to the measured ones.

[Algorithm for the management of patients with stable coronary artery disease and high-grade ventricular arrhythmias].

The paper gives an original algorithm for the management of patients with stable coronary artery disease, preserved/moderately reduced left ventricular systolic function, and high-grade ventricular arrhythmias from the first registration of the latter to the choice of treatment policy. Great attention is paid to the assessment of a private clinical case, by determining the nature of arrhythmias, and to the involvement of autonomic regulation in the genesis of ventricular arrhythmias. The importance of topical diagnosis of ventricular arrhythmias and identification of psychological disorders is emphasized.

Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina.

Objectives: The goal of this study was to assess the safety and tolerability of omecamtiv mecarbil treatment during symptom-limited exercise in patients with ischemic cardiomyopathy and angina. These patients may have increased vulnerability to prolongation of the systolic ejection time.

Background: Omecamtiv mecarbil is a selective cardiac myosin activator that augments cardiac contractility in patients with systolic heart failure through a dose-dependent increase in systolic ejection time.

[A case of effective psychogenic ventricular arrhythmia treatment with the anxiolytic Adaptol].

There is a presents a clinical case of idiopathic ventricular arrhythmia developing in a 27-year-old young woman with anxiety neurosis successfully treated with the anxiolytic Adaptol used in daily dosage 1500 mg during a month.

[First experience of the study "Intramyocardial Multiple Precision Administration of Mononuclear Bone Marrow Cells in the Treatment of Myocardial Ischemia"].

Study aim - to elucidate possibilities of the use of precision administration of mononuclear bone marrow cells (MBMC) for the treatment of myocardial ischemia and heart failure. "Intramyocardial Multiple Precision Administration of Mononuclear Bone Marrow Cells in the Treatment of Myocardial Ischemia" was a double blind randomized placebo controlled study in which we included patients more or equal 6 months after Q-wave myocardial infarction with systolic myocardial dysfunction (ejection fraction <35%), not requiring myocardial revascularization, receiving stable optimal medical therapy for more or equal 8 weeks, and with implanted cardioverter-defibrillator. Transplantation of MBMC was guided by fluoroscopy and tridimensional NOGA XP Cardiac Navigation System.

[In search of optimal treatment for nonischemic ventricular arrhythmia in patients with anxiety disorders].

Aim: To assess whether arrhythmias may be corrected with the anxiolytic Adaptol in subjects with anxiety disorders.

Subjects And Methods: On the basis of the data of psychological and mental testing (Stroop test) and the results of Holter monitoring, the authors selected among 59 patients with non-coronarogenic ventricular arrhythmias (VA) and an inadequate response to antiarrhythmic therapy 21 patients with manifest anxiety disorders, in whom a psychogenic factor had played a significant role in the genesis of VA, which served as an indication for Adaptol use. Reexaminations were made 30 days after initiation of therapy with Adaptol 500 mg t.

[Microvolt T-wave alternans as a novel method of analysis of changes of repolarization phase and detection of latent electrical instability of the myocardium].

This review considers of modern concepts of microvolt T-wave alternans (TWA): its pathophysiological basis at cellular level, particulars of quantitative analysis of TWA, modulating effects of autonomic nervous system and drugs, prognostic efficacy in predicting susceptibility to ventricular arrhythmia in comparison with other modern prognostic factors of sudden cardiac death.

[Tachyinduced cardiomyopathy].

The authors consider modem views on tachyinduced cardiomyopathy, which occurs as a result of an increase in atrial or ventricular contraction rate. Data of experimental and clinical studies are presented. The issues of pathogenesis, the clinical significance, the questions of diagnostics, and possibilities of treatment of tachyinduced cardiomyopathy are reflected.

[A modulated type of ventricular parasystole].

The paper presents data (from 15 case histories) and the methods for ECG analysis of ventricular parasystole of the modulated type with accelerated or delayed paracenter activity entrainment and annihilation phenomena. A relationship between classical and modulated types of parasystole is discussed.

[Comparison of exercise test and ECG monitoring results in women with ischemic heart disease].

To diagnose myocardial ischemia and differentiate the chest pain syndrome in 20 females with coronary heart disease and effort angina pectoris, exercise test and ECG monitoring were performed. Their results were then compared. The informative value of 24-hour ECG monitoring was higher than that of bicycle ergometry in detecting the objective signs of ischemia in patients with effort angina.