Publications by authors named "Tresa E Zacharias"
Sphingosine 1-phosphate (S1P) is a signaling molecule that binds to five G protein-coupled receptors (Proc Natl Acad Sci USA 108:751-756, 2011). Modulation of these receptors has been associated with pleiotropic biological effects in the immune, cardiovascular, and central nervous systems (CNS). The functional S1P receptor antagonist fingolimod was the first member of this class of pharmacotherapeutics to be approved for treatment of relapsing multiple sclerosis (MS).
View Article and Find Full Text PDFArticle Synopsis
- Experimental autoimmune encephalomyelitis (EAE) serves as a key model for studying multiple sclerosis (MS) and this study aimed to improve the protocol for inducing EAE in C57BL/6 mice through adoptive transfer.
- The researchers successfully established a step-wise method that achieved approximately 70% incidence of EAE in recipient mice by using lymph node cells from donor mice immunized with myelin oligodendrocyte glycoprotein (MOG)p35-55.
- Key findings revealed that lymph node cells collected 12 days post-immunization, when restimulated with MOG and interleukin-12, were essential for transferring disease, showing a strong association between inflammatory response and disease susceptibility