Publications by authors named "Trenton M Gibson"
Article Synopsis
- A meta-analysis of RNA-sequencing data from patients with different genetic variants showed that tumors with PMS2 mutations have specific active signaling pathways.
- These pathways are linked to cancer growth and spread, suggesting that PMS2 could be key in understanding tumor behavior and might be targeted for new treatments.
Background: Recent efforts to repurpose existing drugs to different indications have been accompanied by a number of computational methods, which incorporate protein-protein interaction networks and signaling pathways, to aid with prioritizing existing targets and/or drugs. However, many of these existing methods are focused on integrating additional data that are only available for a small subset of diseases or conditions.
Methods: We have designed and implemented a new R-based open-source target prioritization and repurposing method that integrates both canonical intracellular signaling information from five public pathway databases and target information from public sources including OpenTargets.