Publications by authors named "Trent Barnard"
Amorphous drugs represent an intriguing option to bypass the low solubility of many crystalline formulations of pharmaceuticals. The physical stability of the amorphous phase with respect to the crystal is crucial to bring amorphous formulations into the market-however, predicting the timescale involved with the onset of crystallization a priori is a formidably challenging task. Machine learning can help in this context by crafting models capable of predicting the physical stability of any given amorphous drug.
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- The "boson peak" is a phenomenon in glasses tied to excess heat capacity and terahertz vibrations, with unclear origins, possibly linked to locally ordered structures.
- Through depolarised Raman scattering, researchers can observe the boson peak in liquids of symmetric molecules, showing its correlation with heat capacity changes.
- Cooling increases the boson peak's intensity, revealing molecular clusters of about 20 molecules, driven by over-coordinated molecules, advancing our understanding of vitrification physics.