COVID for One: Identifying Obstacles to Self-Management of COVID-19 for Single Adults.

Given the complexities of healthcare provision, it is imperative to understand how single adults experience their interactions with medical professionals and health care organizations, manage care and treatment, and navigate the barriers encountered. This study's purpose is to understand physical and mental health experiences in consideration of social determinants of health, barriers, and coping strategies for single adults diagnosed with COVID-19. An interpretive phenomenology study design was used with 12 individuals who were single and living alone during the COVID-19 pandemic.

Formal synthesis of kibdelomycin and derivatisation of amycolose glycosides.

A convergent total synthesis of bacterial gyrase B/topoisomerase IV inhibitor kibdelomycin (a.k.a.

Dynamics of Above-Threshold Ionization and Laser-Assisted Electron Scattering inside Helium Nanodroplets.

Laser-assisted electron scattering (LAES) is a fundamental three body interaction process that enables energy transfer between electrons and photons in the presence of matter. Here, we focus on the multiscattering regime of electrons generated by above-threshold ionization (ATI) of In atoms inside a high-density nanostructure, helium nanodroplets (He) of ∼40 Å radius. The stochastic nature of the multiscattering regime results in photoelectron spectra independent of laser polarization.

Post-traumatic stress disorder following childbirth: prevalence and associated factors-a prospective cohort study.

Objective: Traumatic experiences during or after childbirth are subject of intense discussions in mainstream and social media as well as in scientific literature. Aim of this evaluation is to estimate the prevalence of post-traumatic stress disorder (PTSD) following childbirth in postpartum women and to evaluate the influence of maternal, obstetrical and neonatal characteristics on the degree of PTSD symptoms measured by the Impact of Events Scale questionnaire (IES-R).

Methods: In total, 589 women who gave birth in the University Medical Center Mainz, Germany in 2016, participated in a survey within the first days after birth.

Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities.

Eight analogues of the bioherbicides macrocidin A () and Z () with structural variance in the size of the macrocycle, its - or -cyclophane character, and its functional groups were synthesized on two modular routes and tested for herbicidal, antibiotic, and antibiofilm activities. Apart from the lead compounds and , the structurally simplified dihydromacrocidin Z () and normacrocidin Z () showed high herbicidal activity in either thistles, dandelions or in both. The derivatives , , and dibromide also inhibited the growth of biofilms by ca 70% when applied at subtoxic concentrations as low as ca 20 µM, which are unlikely to induce bacterial resistance.

Observation of laser-assisted electron scattering in superfluid helium.

Laser-assisted electron scattering (LAES), a light-matter interaction process that facilitates energy transfer between strong light fields and free electrons, has so far been observed only in gas phase. Here we report on the observation of LAES at condensed phase particle densities, for which we create nano-structured systems consisting of a single atom or molecule surrounded by a superfluid He shell of variable thickness (32-340 Å). We observe that free electrons, generated by femtosecond strong-field ionization of the core particle, can gain several tens of photon energies due to multiple LAES processes within the liquid He shell.

Macrooxazoles A-D, New 2,5-Disubstituted Oxazole-4-Carboxylic Acid Derivatives from the Plant Pathogenic Fungus .

In our ongoing search for new bioactive fungal metabolites, four previously undescribed oxazole carboxylic acid derivatives (-) for which we proposed the trivial names macrooxazoles A-D together with two known tetramic acids (-) were isolated from the plant pathogenic fungus . Their structures were elucidated based on high-resolution mass spectrometry (HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The hitherto unclear structure of macrocidin Z () was also confirmed by its first total synthesis.

Emotional sounds guide visual attention to emotional pictures: An eye-tracking study with audio-visual stimuli.

For the realm of visual cues, it has been well documented that attention is preferentially oriented toward emotionally relevant cues. Preliminary evidence suggests that emotional cues from other sensory modalities may also steer visual attention toward emotional pictures. However, more research is needed to elucidate the mechanisms that are involved.

Ultrafast photoinduced dynamics of single atoms solvated inside helium nanodroplets.

Helium nanodroplets can serve as reaction containers for photoinduced time-resolved studies of cold, isolated molecular systems that are otherwise inaccessible. Recently, three different dynamical processes, triggered by photoexcitation of a single atom inside a droplet, were observed in their natural time scale: Expansion of the He solvation shell (He bubble) within 600 fs initiates a collective bubble oscillation with a ∼30 ps oscillation period, followed by dopant ejection after ∼60 ps. Here, we present a systematic investigation of these processes by combining time-resolved photoelectron and photoion spectroscopy with time-dependent He density functional theory simulations.

After the Medication Error: Recent Nursing Graduates' Reflections on Adequacy of Education.

Background: The purpose of this study was to better understand individual- and system-level factors surrounding making a medication error from the perspective of recent Bachelor of Science in Nursing graduates.

Method: Online survey mixed-methods items included perceptions of adequacy of preparatory nursing education, contributory variables, emotional responses, and treatment by employer following the error.

Results: Of the 168 respondents, 55% had made a medication error.

Nurses' rights of medication administration: Including authority with accountability and responsibility.

Medication errors continue to occur too frequently in the United States. Although the five rights of medication administration have expanded to include several others, evidence that the number of errors has decreased is missing. This study suggests that medication rights for nurses as they administer medications are needed.

Making an Infusion Error: The Second Victims of Infusion Therapy-Related Medication Errors.

Infusion therapy-related adverse events can result in distress and professional suffering for the nurse involved with the event, with long-lasting consequences. This article discusses the second victim syndrome and its impacts on nurses. Original research on 168 recent nursing graduates and their experiences with second victim syndrome after making an infusion-related error is also presented.

More Than 1 Million Potential Second Victims: How Many Could Nursing Education Prevent?

Any error made in health care can cause the health care provider to become a second victim. There are many initiatives, tools, and instruments designed to support second victims after an error has been made. The role that nursing education can play in preventing nurses from becoming second victims has not been well explored.

Workplace bullying, perceived job stressors, and psychological distress: Gender and race differences in the stress process.

A large body of empirical research documents the adverse mental health consequences of workplace bullying. However, less is known about gender and race differences in the processes that link workplace bullying and poor mental health. In the current study, we use structural equation modeling of survey data from the 2010 Health and Retirement Study (N = 2292) and draw on stress process theory to examine coworker support as a buffering mechanism against workplace bullying, and gender and race differences in the relationships between bullying and psychological distress.

Dual, Yet Dueling Illnesses: Multiple Chronic Illness Experience at Midlife.

The prevalence of multiple chronic illnesses is increasing dramatically, especially among those in middle adulthood, yet much prior research has focused on the experience of multiple morbidity among older adults. We examined the online illness narratives (blogs) of 10 men and women aged 36 to 59 to better understand the experience of living with multiple chronic illnesses at midlife. Multiple morbidity presents distinct challenges to those at midlife: (a) diagnosis and management of multiple illnesses, (b) need for information, (c) identity dilemmas and threats to self-image, and (d) stigma and social rejection.

When nurses become the "second" victim.

Purpose: Well-intentioned, conscientious nurses make medication errors. The subsequent feelings of guilt, remorse, and loss of personal and professional self-esteem these nurses experience are well documented. In this paper, we analyze the concept of "second victim" within the context of medication administration errors.

Medication errors, routines, and differences between perioperative and non-perioperative nurses.

Despite efforts to reduce the incidence of perioperative medication errors, these errors continue to be a problem. We examined written accounts from 16 nurses who discussed medication errors in the perioperative environment and 11 nurses who provided additional information about perioperative errors, nursing education, and the state of health care. Preoperative medication errors were the most frequently reported perioperative medication errors.

Devastatingly human: an analysis of registered nurses' medication error accounts.

Despite many safeguards, nurses make the majority of medication administration errors. The purpose of our research was to investigate the perceived causes for such errors and to better understand how nurses deal with them. We performed an interpretive analysis of 158 accounts by nurses who made self-identified medication errors.

When the 5 rights go wrong: medication errors from the nursing perspective.

This study describes nurses' perceptions about how and why medication errors occur and their personal experiences with medication errors. A survey was mailed to a random sample of registered nurses. Two hundred and two responded.

Screening for diabetes in an African-American community: the Project DIRECT experience.

Aim: To report the results of a community-based screening program associated with Project DIRECT, a multiyear diabetes mellitus prevention and control project targeting African-American residents of southeast Raleigh, NC.

Methods: Between December 1996 and June 1999, 183 screening events took place in community settings. Screening was by capillary glucose concentration.

Origin of monacolin L from Aspergillus terreus cultures.

In freshly harvested Aspergillus terreus cultures grown for the production of lovastatin (formerly called mevinolin), no monacolin L could be detected. However, during the isolation of lovastatin, significant quantities of monacolin L appeared. It has been discovered that a new metabolite structurally related to the members of the monacolin series is present.

Quantitative thin-layer chromatography in accelerated stability studies for prediction of inherent sensitivity of drugs toward oxygen.

This paper discusses a novel technique for studying the inherent sensitivity of materials toward oxygen and the utility of quantitative thin-layer chromatography, as a tool in such studies. The degradation generally followed first order kinetics up to about 60% decomposition, indicating that the usual kinetic treatment applied to homogeneous systems can be used. The method can also detect degradation products, in many cases adding a considerable diagnostic element to its predictive value.

Quantitative analysis of cephamycin C in fermentation broths by means of thin-layer spectrodensitometry.

A method has been developed that consists of one-dimensional thin-layer chromatography of the samples on pre-coated silica gel 60F254 plates followed by an in situ spectrophotometric evaluation of the chromatograms at 273 nm. Statistical evaluations showed a linear calibration (r2 greater than 0.999) for the range of 0.