Experimental study of the effect of a new antioxidant agent on learning and memory.

This work presents the results of studying the effect of a new antioxidant compound enoxyphol on learning and memory in rats.

[Antioxidants: current situation and perspectives].

In the overview one can find analysis medico-biological aspects of free radical theory, clinical experience of antioxidants using, perspectives of new active agents and possible directions of theirs practical use.

[Modelling of intrauterine hypoxia].

An experimental model of chronic intrauterine hypoxia is proposed. This model reflects the most typical posthypoxic impairments for the above pathology: intrauterine growth retardation, alterations in the placental parameters, posterity death in the neonatal period, physical retardation, postnatal disorders in the CNS functions.

[New models of inheritance of complex characteristics and their use in segregation analysis of idiopathic scoliosis].

New methods of segregation analysis of alternative traits have been developed. These methods make it possible to take into account the sex and age specificity of the disease manifestation. Hence, they extend the range of genetic hypotheses to be tested and ensure the correct analysis of inheritance of complex pathologies in humans.

Segregation analysis of idiopathic scoliosis: demonstration of a major gene effect.

Segregation analysis using a model with age and gender effects was applied to 101 pedigrees ascertained through a proband with idiopathic scoliosis. The transmission probability model was used to detect major gene effect. When we analyzed the pedigrees where affected status was assigned to persons with a Cobb's angle of more than 5 degrees we did not detect a significant major gene effect.