Airway Management in Tactical Combat Casualty Care: TCCC Change 24-1.

Tactical Combat Casualty Care (TCCC) has been designated by the U.S. Department of Defense as the military standard for battlefield trauma care.

Improving Outcomes Associated with Prehospital Combat Airway Interventions: An Unrealized Opportunity.

Background: Airway obstruction is the second leading cause of potentially survivable death on the battlefield. Assessing outcomes associated with airway interventions is important, and temporal trends can reflect the influence of training, technology, the system of care, and other factors. We assessed mortality among casualties undergoing prehospital airway intervention occurring over the course of combat operations during 2007-2019.

TCCC Guidelines Comprehensive Review and Edits 2020: TCCC Guidelines Change 20-05 01 November 2020.

Based on careful review of the Tactical Combat Casualty Care (TCCC) Guidelines, the authors developed a list of proposed changes and edits for inclusion in a comprehensive change proposal. To be included in the proposal, individual changes had to meet at least one of three criteria: 1. The change was primarily tactical, operational, or educational rather than clinical in nature.

Elucidating the origins of enhanced CO reduction in manganese electrocatalysts bearing pendant hydrogen-bond donors.

Complexes of the general form [Mn(X)(CO)bpy] (X = a variety of monodentate ligands, bpy = 2,2'-bipyridine) have been reported to act as electrocatalysts for the reduction of CO to CO. In this work, a series of phenol and anisole substituted bipyridine ligands were synthesized and ligated to a manganese metal center in order to probe for an intramolecular hydrogen-bonding interaction in the transition state of CO reduction. Ligands without the ability to intramolecularly hydrogen bond displayed decreased catalytic current density compared to those with the ability to hydrogen bond with CO.

TCCC Guidelines Comprehensive Review and Update: TCCC Guidelines Change 16-03.

Based on careful review of the Tactical Combat Casualty Care (TCCC) Guidelines, the authors developed a list of proposed changes for inclusion in a comprehensive change proposal. To be included in the proposal, individual changes had to meet at least one of three criteria: (1) The change was primarily tactical rather than clinical; (2) the change was a minor modification to the language of an existing TCCC Guideline; and (3) the change, though clinical, was straightforward and noncontentious. The authors presented their list to the TCCC Working Group for review and approval at the 7 September 2016 meeting of the Committee on Tactical Combat Casualty Care (CoTCCC).

Design of a Catalytic Active Site for Electrochemical CO2 Reduction with Mn(I)-Tricarbonyl Species.

The design, synthesis, and assessment of a new manganese-centered catalyst for the electrochemical reduction of CO2 is described. The reported species, MnBr(6-(2-hydroxyphenol)-2,2'-bipyridine)(CO)3, includes a ligand framework with a phenolic proton in close proximity to the CO2 binding site, which allows for facile proton-assisted C-O bond cleavage. As a result of this modification, seven times the electrocatalytic current enhancement is observed compared to MnBr(2,2'-bipyridine)(CO)3.

Exploring the effect of axial ligand substitution (X = Br, NCS, CN) on the photodecomposition and electrochemical activity of [MnX(N-C)(CO)3] complexes.

The synthesis, electrochemical activity, and relative photodecomposition rate is reported for four new Mn(i) N-heterocyclic carbene complexes: [MnX(N-ethyl-N'-2-pyridylimidazol-2-ylidine)(CO)3] (X = Br, NCS, CN) and [MnCN(N-ethyl-N'-2-pyridylbenzimidazol-2-ylidine)(CO)3]. All compounds display an electrocatalytic current enhancement under CO2 at the potential of the first reduction, which ranges from -1.53 V to -1.

NHC-containing manganese(I) electrocatalysts for the two-electron reduction of CO2.

The synthesis and characterization of the first catalytic manganese N-heterocyclic carbene complexes are reported: MnBr(N-methyl-N'-2-pyridylbenzimidazol-2-ylidine)(CO)3 and MnBr(N-methyl-N'-2-pyridylimidazol-2-ylidine)(CO)3. Both new species mediate the reduction of CO2 to CO following two-electron reduction of the Mn(I) center, as observed with preparative scale electrolysis and verified with (13)CO2. The two-electron reduction of these species occurs at a single potential, rather than in two sequential steps separated by hundreds of millivolts, as is the case for previously reported MnBr(2,2'-bipyridine)(CO)3.

Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies.

The use of small molecules that can promote neuronal growth represents a promising approach to regenerative science. Along these lines we have developed separate short or modular syntheses of the natural products caryolanemagnolol and clovanemagnolol, small molecules previously shown to promote neuronal growth and induce choline acetyltransferase activity. The postulated biosynthetic pathways, potentially leading to the assembly of these molecules in nature, have guided the laboratory syntheses, allowing the preparation of both natural products in as few as two steps.

Hydroxyl-directed cyclizations of 1,6-enynes.

The palladium-catalyzed, hydroxyl-directed cyclization reactions of 1,6-enynes provide a highly diastereoselective process for the syntheses of stereochemically defined cyclopentanes. Consistently high levels of cis-selectivity are possible using homopropargyl alcohols in contrast to the corresponding propargyl alcohols. Hydroborylative enyne cyclizations coupled with this directing group effect provide a useful method for the syntheses of multifaceted compounds bearing all carbon quaternary centers.

Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol.

Separate short and modular syntheses of the isomeric natural products caryolanemagnolol and clovanemagnolol have been achieved starting from commercially available (-)-caryophyllene. The postulated biosynthetic pathways guided the syntheses of the neuroregenerative small molecules allowing their assembly in as few as two steps.

Elective parotidectomy in the management of advanced auricular malignancies.

Objective: The purpose of this study is to determine whether elective parotidectomy is necessary in patients with clinically and radiographically N0 parotid disease with isolated primary auricular nonmelanoma cutaneous malignancies. Auricular malignancies are typically managed by wedge resection or wide local excision. Although small lesions are easily managed by conservative excision, large bulky tumors, those with multifocal involvement, and recalcitrant lesions, often require more extensive resection including total auriculectomy, parotidectomy, and/or neck dissection.

Traumatic cholesteatoma presenting as a brain abscess: a case report.

Objective: To discuss the clinical aspects and management of traumatic cholesteatomas of the temporal bone.

Study Design: Case report.

Setting: University hospital, tertiary referral center.