Use of Liposomal Bupivacaine for Postoperative Analgesia in an Incisional Pain Model in Rats ().

The local anesthetic bupivacaine is valuable for perioperative analgesia, but its use in the postoperative period is limited by its short duration of action. Here, we evaluated the application of a slow-release liposomal formulation of bupivacaine for postoperative analgesia. The aim was to assess whether liposomal bupivacaine effectively attenuates postoperative mechanical and thermal hypersensitivity in a rat model of incisional pain.

Evaluation of Isoflurane Overdose for Euthanasia of Neonatal Mice.

Neonatal mice (that is, pups younger than 6 d) must be exposed to CO2 for as long as 50 min to achieve euthanasia. Alternatively, other inhalant anesthetic agents have been used to euthanize laboratory rodent species. We investigated the efficacy of isoflurane at saturated vapor pressure to euthanize neonatal mice.

Postoperative Analgesia Due to Sustained-Release Buprenorphine, Sustained-Release Meloxicam, and Carprofen Gel in a Model of Incisional Pain in Rats (Rattus norvegicus).

Postoperative analgesia in laboratory rats is complicated by the frequent handling associated with common analgesic dosing requirements. Here, we evaluated sustained-release buprenorphine (Bup-SR), sustained-release meloxicam (Melox-SR), and carprofen gel (CG) as refinements for postoperative analgesia. The aim of this study was to investigate whether postoperative administration of Bup-SR, Melox-SR, or CG effectively controls behavioral mechanical and thermal hypersensitivity in a rat model of incisional pain.

Combining blink, pupil, and response time measures in a concealed knowledge test.

The response time (RT) based Concealed Knowledge Test (CKT) has been shown to accurately detect participants' knowledge of mock-crime-related information. Tests based on ocular measures such as pupil-size and blink-rate have sometimes resulted in poor classification, or lacked detailed classification analyses. The present study examines the fitness of multiple pupil and blink related responses in the CKT paradigm.

Brain activation evidence for response conflict in the exclude recognition task.

How do memory retrieval processes (i.e., familiarity and recollection processes) interact with motor and control processes to bring about an appropriate response? Our parallel task-set model predicts, and behavioral and electromyographic data support, the hypothesis that under some circumstances familiarity and recollection processes activate competing responses.

Relief of branch pulmonary artery stenosis reduces pulmonary valve insufficiency in a swine model.

Objective: We sought to determine the impact of relieving branch pulmonary artery stenosis on pulmonary valve insufficiency and right ventricular function. Long-standing pulmonary insufficiency causes progressive right ventricular dilatation, leading to decreased right ventricular function. Adults with pulmonary insufficiency are at risk of decreased exercise tolerance, arrhythmias, and sudden cardiac death.

Time and encoding effects in the concealed knowledge test.

Although the traditional "lie detector" test is used frequently in forensic contexts, it has (like most test of deception) some limitations. The concealed knowledge test (CKT) focuses on participants' recognition of privileged knowledge rather than lying per-se and has been studied extensively using a variety of measures. A "guilty" suspect's interaction with and memory of crimescene items may vary.

Electromyographic evidence for response conflict in the exclude recognition task.

How do memory retrieval processes lead to overt responses in strategic recognition tasks (responding "old" to one class of familiar stimulus and "new" to another)? Many current theories of memory retrieval ignore the response requirements in such memory tasks, instead modeling them using memory processes (e.g., familiarity and recollection) alone (see Yonelinas, 2002).

Aging and goal-directed emotional attention: distraction reverses emotional biases.

Previous findings reveal that older adults favor positive over negative stimuli in both memory and attention (for a review, see Mather & Carstensen, 2005). This study used eye tracking to investigate the role of cognitive control in older adults' selective visual attention. Younger and older adults viewed emotional-neutral and emotional-emotional pairs of faces and pictures while their gaze patterns were recorded under full or divided attention conditions.

Substrate characterization of ventricular tachycardia in a porcine model of tetralogy of Fallot using noncontact mapping.

Background: Ventricular tachycardia (VT) in patients following tetralogy of Fallot (TOF) repair is challenging to map because of the presence of scar, patch material, and hemodynamic residua of surgery. This study investigates whether noncontact mapping can identify the arrhythmia substrate in a porcine model that involves a right ventricular outflow tract (RVOT) patch and either chronic volume or pressure load on the right ventricle.

Methods: Nine infant pigs (3-5 kg) underwent surgery involving an RVOT patch and creation of pulmonary insufficiency (PI, n = 4) or pulmonary stenosis (PS, n = 5).

Theoretical implications of articulatory duration, phonological similarity, and phonological complexity in verbal working memory.

The phonological-loop model provides a prominent theoretical description of verbal working memory. According to it, serial recall accuracy should be inversely related to the articulatory duration and phonological similarity of verbal items in memorized sequences. Initial tests of these predictions by A.