Publications by authors named "Travis Philyaw"
Adrenergic modulation of voltage gated Ca currents is a context specific process. In the heart Ca1.2 channels initiate excitation-contraction coupling.
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- Psychostimulants like cocaine and amphetamines enhance dopamine activity in the brain's reward system, leading to addiction but also serving as treatments for ADHD and ASD.
- The complex interplay between addiction and therapeutic effects is influenced by genetic factors, yet few related genes are identified due to the need for large, diverse study samples.
- Using fruit flies as a model offers an efficient way to study these genetic components since they share behavioral similarities with humans and can effectively show responses to psychostimulants.
Chromosome 22q13.3 deletion (Phelan McDermid) syndrome (PMS) is a rare genetic neurodevelopmental disorder resulting from deletions or other genetic variants on distal 22q. Pathological variants of the SHANK3 gene have been identified, but terminal chromosomal deletions including SHANK3 are most common.
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