Publications by authors named "Trapti Sharma"

Background: The prognosis of lung carcinoma has changed since the discovery of molecular targets and their specific drugs. Somatic Epidermal Growth Factor Receptor () mutations have been reported in lung carcinoma, and these mutant proteins act as substrates for targeted therapies. However, in a resource-constrained country like India, panel-based next-generation sequencing cannot be made available to the population at large.

View Article and Find Full Text PDF

Vaccine development is a complex and long process. It involves several steps, including computational studies, experimental analyses, animal model system studies, and clinical trials. This process can be accelerated by using in silico antigen screening to identify potential vaccine candidates.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers created an interactive network mapping the relationships between various biological molecules, analyzing over 10,000 research articles to build a comprehensive scale-free network consisting of diverse proteins, genes, and known drugs.
  • * Large-scale docking studies revealed that existing FDA-approved drugs, specifically benznidazole and nifurtimox, demonstrate strong binding affinities to key proteins in the network, potentially aiding in the development of new vaccines and treatments for Chagas disease.
View Article and Find Full Text PDF

An unusual pneumonia infection, named COVID-19, was reported on December 2019 in China. It was reported to be caused by a novel coronavirus which has infected approximately 220 million people worldwide with a death toll of 4.5 million as of September 2021.

View Article and Find Full Text PDF

The development of a new vaccine is a challenging exercise involving several steps including computational studies, experimental work, and animal studies followed by clinical studies. To accelerate the process, in silico screening is frequently used for antigen identification. Here, we present Vaxi-DL, web-based deep learning (DL) software that evaluates the potential of protein sequences to serve as vaccine target antigens.

View Article and Find Full Text PDF

Antigen identification is an important step in the vaccine development process. Computational approaches including deep learning systems can play an important role in the identification of vaccine targets using genomic and proteomic information. Here, we present a new computational system to discover and analyse novel vaccine targets leading to the design of a multi-epitope subunit vaccine candidate.

View Article and Find Full Text PDF