Detection of EWS/FLI-1 fusion in non-Ewing soft tissue tumors.

Objectives: EWS/FLI-1 fusion mainly appears in Ewing's sarcoma or the primitive neuroectodermal tumors and represents a genomic marker for these tumors. However, it can appear with lower frequency in other soft tissue tumors. The paper investigates the presence of EWS/FLI-1 fusion in clinically diagnosed sarcoma belonging to different non-Ewing connective tissue tumors in order to search for a possible new biomarker valuable for investigators.

Detection of EWS/FLI-1 fusion in non-Ewing soft tissue tumors.

Objectives: EWS/FLI-1 fusion mainly appears in Ewing's sarcoma or the primitive neuroectodermal tumors and represents a genomic marker for these tumors. However, it can appear with lower frequency in other soft tissue tumors. The paper investigates the presence of EWS/FLI-1 fusion in clinically diagnosed sarcoma belonging to different non-Ewing connective tissue tumors in order to search for a possible new biomarker valuable for investigators.

Chromosomal translocations highlighted in Primitive Neuroectodermal Tumors (PNET) and Ewing sarcoma.

Almost 200 molecular markers in oncology, very important in the diagnosis, prognostic and treatment were identified. The cell and tissue markers and also the circulating (sanguine) ones are genetic markers of the hereditary and non-hereditary tumors. Also extremely important are the regulatory ways of cell growth and differentiation, of the cell "senescence" and cell death (apoptosis).