Publications by authors named "Tran-Thi Chinh"
Genetic variation in tumor virus genes and its impact on function might contribute to the understanding of geographic differences in risks for virus-associated tumors. This is particularly true for the genes known to contribute to the biology of the tumor. It is has been proposed that Epstein-Barr virus (EBV) gene variation has a role in the high risk of nasopharyngeal carcinoma (NPC) in South-East Asia.
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- EBV nuclear antigen 1 (EBNA1) is crucial for maintaining Epstein-Barr virus (EBV) latent infection, regulating both virus replication and gene expression.
- A specific sub-variant of EBNA1, identified as V-val-v1, was found in various samples from both NPC patients and healthy donors across Southeast Asia, indicating its significance in EBV-related diseases.
- Research showed that EBNA1 and the FR-region from Asian isolates resulted in greater transcriptional activity compared to those from the B95-8 strain, suggesting potential differences in viral behavior across geographic regions.