Culcinoside E, a new sulfated steroidal biglycoside from the starfish .

Using various chromatographic separations, six steroid glycoside derivatives, including one new compound named culcinoside E (), were isolated from the methanol extract of the starfish . Their structures were confirmed by detailed analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. Among isolated compounds, culcinoside E (), diplasterioside A (), and thornasteroside A () inhibited growth of , whereas culcitoside C () was active on .

Psychometric properties of the New General Self-Efficacy Scale for Vietnamese persons with colorectal cancer.

Background: There are currently no specific tools available to assess self-efficacy among Vietnamese individuals with colorectal cancer (CRC) post-surgery. Translating and evaluating the psychometric properties of the New General Self-Efficacy Scale (NGSE) for use in the Vietnamese population could help address this gap.

Objective: This study aimed to evaluate the psychometric properties of the Vietnamese version of the NGSE scale.

A causal model of health-related quality of life in colorectal cancer patients post-surgery.

Purpose: this study aims to develop and test a model examining the causal relationship between self-efficacy, social support, fatigue, pain, functional status, and health-related quality of life (HRQL).

Methods: A cross-sectional correlation study was conducted using a multi-stage sampling technique to recruit 256 individuals aged 20 to 59 with colorectal cancer (CRC) post-surgery from three hospitals in Northern Vietnam. The hypothesized model, based on Ferrans' HRQL conceptual model and literature review, was validated using structural equation modeling (SEM) and Mplus.

Translation and Validation of a Vietnamese Version of the Colorectal Cancer Subscale for the Functional Assessment of Cancer Therapy - Colorectal Questionnaire.

Introduction: There is a need for a validated Vietnamese translation of the colorectal cancer subscale (CCS) of the functional assessment of cancer therapy-colorectal (FACT-C) questionnaire to assess colorectal cancer-specific concerns of Vietnamese persons with colorectal cancer post-surgery.

Objectives: This study aims to translate and validate the CCS of FACT-C questionnaire in Vietnamese persons with colorectal cancer post-surgery.

Methods: The nine-item CCS was translated following the functional assessment of chronic illness therapy (FACIT) translation methodology guidelines.

Glycoside constituents from .

Using various chromatographic separations, six glycoside derivatives (), including one new -labdane glucoside named cayratioside (), were isolated from the methanol extract of stems and leaves. Their structures were elucidated by detailed analysis of the 1D, 2D NMR, and HRESIQTOF mass spectra. The inhibitory effect of on LPS-induced NO production in RAW264.

Caffeoylquinic acid esters, lignans and flavones from with cytotoxic and nitric oxide inhibitory activities.

Phytochemical study on the aerial parts of resulted in the isolation of 11 secondary metabolites, including a new caffeoyl quinic acid derivative, 3---caffeoyl-4--acetylquinic acid methyl ester (), a new dihydrobenzofuran neolignan, 3,5-dimethoxy-4-(1″,3″-dihydroxy-2″-propyloxyl)-4',7-epoxy-8,5'-neolignan-4,9,9'-triol () and nine known compounds, methyl 4--coumaroylquinate (), (7*,8*)-3-methoxy-3',7-epoxy-8,4'-oxyneolignan-4,9,9'-triol (), kompasinol A (), lyoniresinol (), schizandriside (), (-)-isolariciresinol 3a---D-xylopyranoside (), lyoniside (), vitexin () and luteolin 4'---glucopyranoside (). Their structures were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR and HRESI mass spectra. The absolute configurations of and were deduced by electronic circular dichroism spectroscopy.

Acylated flavonoid glycosides from Barringtonia pendula and their inhibition on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Six new acylated flavonoid glycosides namely barringosides J - O (1-6) along with tephrokaempferoside and barringoside D were isolated from the branches and leaves of Barringtonia pendula. The structural elucidation was confirmed by extensive analysis of their spectroscopic data including HRQTOFMS, 1D and 2D NMR experiments. Moderate inhibitory effects on LPS-induced NO production in RAW264.

Diterpenoid and phenolic constituents from corn silk () with PTP1B inhibitory activity.

Chemical investigation of corn silk resulted in the isolation of nine secondary metabolites, including a new -kaurane diterpenoid, zeamaysditerpene A () and eight known compounds, stigmaydene A (), stigmaydene J (), stigmaydene L (), stigmane D (), demethyltorosaflavone D (), chrysoeriol 6---boivinopyranosyl-7---D-glucopyranoside (), deoxypodophyllotoxin (), and -peltatin glucoside (). Their structures were elucidated using a combination of spectroscopic methods, including 1D and 2D NMR and HRESIQTOF mass spectra. The absolute configuration of was deduced by applying electronic circular dichroism (ECD) calculation method.

Asterosaponins from the starfish .

Five asterosaponins (-), including one new compound named protonodososide (), were isolated from the methanol extract of the starfish , after subjecting to various chromatographic separations. The structural elucidation was confirmed by careful analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. The cytotoxicity of isolated compounds was evaluated on five human cancer cell lines including HepG2, KB, MCF7, LNCaP, and SK-Mel2.

Isoryanodane diterpene derivatives from .

From the MeOH residue of branches and leaves, one new isoryanodane diterpene, barringisol (), and two new isoryanodane diterpene glucosides, barringisosides A and B ( and ), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from species.

Antimicrobial secondary metabolites from the aerial parts of .

Phytochemical research of aerial parts led to isolation of 12 secondary metabolites, including one new 3-benzoxepin glucoside, perillafrutoside A (), one new megastigmane glycoside, perillafrutoside B (), and 10 known compounds. Their chemical structures were identified based on 1D/2D NMR, HRESIMS, and ECD spectroscopic analyses. The structure of was elucidated based on revision of the previously reported stereoisomer, (6,9)-blumenyl α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside.

Phenolic Glycosides from the Leaves of Iodes cirrhosa Turcz. with Cytotoxic and Antimicrobial Effects.

In the present study, 14 phenolic glycosides, including one new neolignan glycoside, iodescirrhoside A (1), three new flavonol glycosides, iodescirrhosides B-D (2-4), and 10 known metabolites were obtained from the methanol extract of Iodes cirrhosa leaves. Structural elucidation was performed by interpretating the 1D- and 2D- NMR, HR-ESI-MS, and CD spectra in comparison with literature data. All compounds were noncytotoxic to LU-1, HepG2, MCF-7, SK-Mel-2, and LNCaP cancer cell lines.

Secondary metabolites from the fruit peels of L. and their cytotoxic activity.

Three new glucosides, ziberthinosides A-C (1-3), and six known compounds, cleomiscosins A-D (4-7), sporogen AO-2 (8) and sapinofuranone A (9), were isolated from a methanol extract of fruit peels. Their chemical structures were elucidated by analyses of their 1 D/2D NMR and HR-ESI-MS data as well as by comparison with the literature values. The absolute configuration of sporogen AO-2 (8) was confirmed by ECD calculation.

Two new eudesmane sesquiterpene glucosides from the aerial parts of .

Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A () and B (), and two known analogs ainsliaside E () and pumilaside A () were isolated from the aerial parts of . Their chemical structures were established by spectroscopic methods, including one and two-dimensional nuclear magnetic resonance (1 D and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). In addition, their cytotoxicity on five human cancer cell lines, including KB (epidermoid carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), SK-Mel-2 (melanoma), and LNCaP (prostate cancer) was also evaluated by the SRB assay.

Cytotoxic and nitric oxide inhibitory activities of triterpenoids from L.

Using combined chromatographic separation techniques, three new triterpenoids named lycomclavatols A-C (-), a new natural product, methyl lycernuate-A (), as well as seven known compounds (-), were isolated from the methanol extract of the whole plants of . Their chemical structures were established based on 1 D/2D NMR and HR-ESI-MS spectroscopic analyses. Among the isolates, compound exhibited inhibitory activity on NO production in LPS-stimulated BV2 cells (IC = 36.

Cembranoids from the Vietnamese soft coral .

Using various chromatographic separations, two new cembranoids, ehrenbergols F and G ( and ), along with three known analogs ehrenbergol D (), (+)-isosarcophine () and sinulariol Z () were isolated from the soft coral . The structural elucidation was done by extensive analysis of the 1 D and 2 D NMR, HR-ESI-QTOF-MS as well as CD experiments. In addition, compounds (IC of 38.

Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi.

Fourteen polyhydroxylated steroids including six new compounds, ehrensteroids A - F (1-6), were isolated from the Vietnamese soft coral Sarcophyton ehrenbergi after applying various chromatographic separations. The structure elucidation was done by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. In addition, significant cytotoxicity (IC values ranging from 8.

Dammarane-type triterpenoid saponins from the flower buds of with cytotoxic activity.

Phytochemical investigation of a methanol extract of flower buds resulted in the isolation of 22 dammarane-type triterpenoid saponins, including three new compounds, pseudoginsenosides A-C (-), and 19 known analogs. Their chemical structures were identified by the comprehensive spectroscopic methods, including 1 D and 2 D NMR and mass spectra. In addition, their cytotoxic effects toward three human carcinoma cell lines, including liver (HepG2), breast (MCF7), and lung (A549) were also evaluated.

Polyacetylene and phenolic constituents from the roots of .

Chemical investigation of the roots of resulted in isolation of 12 compounds, including one new polyacetylene, codojavanyol (), one new phenolic glycoside, codobenzyloside (), and 10 known compounds, (2,8)-9-(tetrahydro-2-pyran-2-yl)nona-2,8-diene-4,6-diyl-1-ol (), lobetyol (), lobetyolin (), lobetyolinin (), cordifolioidyne B (), benzyl--L-arabinopyranosyl (1-6)--D-glucopyranoside (), ()-8--D-glucopyranosyloxycinnamic acid (), syringin (), syringaresinol (), and tryptophan (). Their structures were elucidated by 1 D and 2 D NMR and MS spectroscopic analyses in comparison with the data reported in the literature. The stereochemistry of the C-2' position of was identified based on time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation.

Secondary metabolites from a peanut-associated fungus IMBC-NMTP01 with cytotoxic, anti-inflammatory, and antimicrobial activities.

Chemical investigation of a peanut-associated fungal strain IMBC-NMTP01 resulted in isolation and identification of 14 secondary metabolites, including two new, -aspergillusol () and aspernigin (), and 12 known compounds: pyrophen (), 2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid (), aspergillusol A (), rubrofusarin B (), nigerasperone A (), fonsecin (), TMC-256C1 (), pyranonigrin A (), orlandin (), nigerasperone C (), asperpyrone A (), and 5-(hydroxymethyl)-2-furancarboxylic acid (). Compounds , showed cytotoxicity toward all six human cancer cell lines, including HepG2, KB, HL-60, MCF-7, SK-Mel2, and LNCaP, with IC values ranging from 8.4 to 84.

Chemical Constituents from the Branches and Leaves of Alchornea trewioides.

Two new megastigmane glucosides namely trewiosides A (1) and B (2), along with 20α-hydroxypregn-4-en-3-one β-D-glucopyranoside (3), sugeroside (4), and schizandriside (5) were isolated from the branches and leaves of Alchornea trewioides. The structure elucidation was confirmed by extensive analysis of the one and two dimensional (1 and 2D) NMR, electronic circular dichroism (ECD) as well as high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra. Noteworthily, the isolation of compounds 1 and 2 represents the second finding of megastigmane derivatives with a methoxycarbonyl group at C-5 to date.

Chemical constituents from the branches and leaves of .

Phytochemical investigation of the branches and leaves of led to isolation of ten secondary metabolites, including two new megastigmane glucosides alnamicosides A () and B (). The structure elucidation was confirmed by 1 D and 2 D NMR, ECD as well as HR-QTOF-MS experiments. The megastigmane derivatives - exhibited inhibitory effects on LPS-induced NO production in RAW264.

Phenolic glycosides from .

Two new phenolic glycosides, oroxylumosides A () and B (), along with four known compounds darendoside A (), leucosceptoside A (), acteoside () and decaffeoylacteoside () were isolated from the stem bark of . Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds - exhibited inhibitory effects on NO production in LPS-stimulated BV2 microglial cell line with IC values of 58.

Polyhydroxylated steroid derivatives from the starfish .

A new polyhydroxysteroid glycoside, regulusoside D (), and a new polyhydroxylated steroid, (24)-cholestane-3,5,6,8,15,24-hexol (), together with seven known compounds were purified from the starfish collected near Con Co Islands, Vietnam. The structure elucidation was confirmed by extensive analysis of their NMR and HR-QTOF mass experiments. Among isolated compounds, regulusoside D (), (24)-cholestane-3,5,6,8,15,24-hexol (), granulatoside A (), 5-cholestane-3,6,7α,15,16,26-hexol (), 5-cholestane-3,6,7,8,15,16,26-heptol () and 5-cholestane-3,6,8,15,16,26-hexol () exhibited strong inhibitory effects on LPS-induced NO production in RAW264.