Publications by authors named "Tran Minh Hung"
Article Synopsis
- Rifampicin (RIF) shows significant variability in how it's processed in different individuals, affecting treatment outcomes and drug resistance in tuberculosis (TB) patients.
- A study in Korea examined how both genetic factors (like SLCO1B1 genotypes) and non-genetic factors contribute to this variability and established recommended RIF doses based on patient weight.
- The findings indicated that body weight and certain genetic variations influence RIF exposure levels, leading to tailored dosing suggestions for patients grouped by weight bands to improve treatment effectiveness.*
Article Synopsis
- * Data from 837 patients in Korea helped establish a two-compartment PK model, identifying body weight and renal function as key factors affecting how EMB is cleared from the body.
- * Findings suggest specific dosing recommendations for different renal function groups to ensure optimal drug effectiveness, enhancing understanding of EMB's pharmacodynamics.
Advancing personalized medicine for tuberculosis through the application of immune profiling.
Front Cell Infect Microbiol
February 2023
While early and precise diagnosis is the key to eliminating tuberculosis (TB), conventional methods using culture conversion or sputum smear microscopy have failed to meet demand. This is especially true in high-epidemic developing countries and during pandemic-associated social restrictions. Suboptimal biomarkers have restricted the improvement of TB management and eradication strategies.
View Article and Find Full Text PDFNon-government organizations (NGOs) spend substantial time and resources collecting baseline data in order to plan and implement health interventions with marginalized populations. Typically interviews with households, often mothers, take over an hour, placing a burden on the respondents. Meanwhile, estimates of numerous health and social indicators in many countries already exist in publicly available datasets, such as the Demographic and Health Surveys (DHS) and the Multiple Indicator Cluster Surveys (MICS), and it is worth considering whether these could serve as estimates of baseline conditions.
View Article and Find Full Text PDFUnlabelled: Background HIV prevalence among men who have sex with men (MSM) and transgender women (TGW) in Vietnam is high, whereas coverage of effective HIV prevention services has been inadequate. Studies have measured MSM and TGW demand for pre-exposure prophylaxis (PrEP) services, which led to the design of the first ever PrEP program in Vietnam, Prepped for PrEP (P4P).
Methods: In March 2017, PrEP services were offered in Ho Chi Minh City as part of the P4P demonstration project, enabling same-day enrolment in three key population (KP)-led clinics and four public clinics.