Engaging older adults in diagnostic safety: implementing a diagnostic communication note sheet in a primary care setting.

Introduction: Adults over the age of 65 are at a higher risk for diagnostic errors due to a myriad of reasons. In primary care settings, a large contributor of diagnostic errors are breakdowns in information gathering and synthesis throughout the patient-provider encounter. Diagnostic communication interventions, such as the Agency for Healthcare Research and Quality's "Be the Expert on You" note sheet, may require adaptations to address older adults' unique needs.

Supporting students through the COVID-19 pandemic: the perspectives of food pantry workers.

Background: College students in the United States are disproportionately impacted by food insecurity, which is associated with diminished health outcomes and poor academic performance. One key resource to support students through periods of food insecurity are on-campus food pantries, which distribute food, personal hygiene products, and other essential items. But as colleges and universities navigated through the COVID-19 pandemic, many campuses closed their food pantries as the demand for their services among students grew.

Mixed lipopeptide-based mucosal vaccine candidate induces cross-variant immunity and protects against SARS-CoV-2 infection in hamsters.

The global dissemination of SARS-CoV-2 led to a worldwide pandemic in March 2020. Even after the official downgrading of the COVID-19 pandemic, infection with SARS-CoV-2 variants continues. The rapid development and deployment of SARS-CoV-2 vaccines helped to mitigate the pandemic to a great extent.

Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles.

Polymeric nanoparticles (NPs) are promising tools used for immunomodulation and drug delivery in various disease contexts. The interaction between NP surfaces and plasma-resident biomolecules results in the formation of a biomolecular corona, which varies patient-to-patient and as a function of disease state. This study investigates how the progression of acute systemic inflammatory disease influences NP corona compositions and the corresponding effects on innate immune cell interactions, phenotypes, and cytokine responses.

Continuous cell type diversification throughout the embryonic and postnatal mouse visual cortex development.

The mammalian cortex is composed of a highly diverse set of cell types and develops through a series of temporally regulated events that build out the cell type and circuit foundation for cortical function. The mechanisms underlying the development of different cell types remain elusive. Single-cell transcriptomics provides the capacity to systematically study cell types across the entire temporal range of cortical development.

Bilateral breast swelling in a pregnant woman with high-grade B-cell lymphoma, potentially Burkitt lymphoma.

Primary breast Burkitt lymphoma is an aggressive subtype of non-Hodgkin lymphoma (NHL) and extremely rare. Burkitt lymphoma involving both breasts during pregnancy was a rare condition with fifteen cases reported in literature. We present a case of a 19-year-old 36 weeks pregnant woman who came for a check-up due to bilateral breast swelling.

CD44 in myEloid cells is a major driver of liver inflammation and injury in alcohol-related liver disease.

Background And Aims: Alcohol-related liver disease (ALD) is one of the leading causes of severe liver disease with limited pharmacological treatments for alcohol-related steatohepatitis (ASH). CD44, a glycoprotein mainly expressed in immune cells, has been implicated in multiple inflammatory diseases but has never been studied in the ALD context. We therefore studied its contribution to ASH development in mice and its expression in ALD patients.

Serum Nutrients, Periodontitis and Biological Ageing.

Introduction: Telomeres are nucleotide sequences found at the end of chromosomes, and their shortening is associated with chronological and biological ageing, oxidative stress and malnutrition. Shorter telomeres have been shown to be associated with periodontitis. Dietary nutrients are also influential factors in the aetiology and progression of periodontitis and other chronic inflammatory diseases.

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis.

Hepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver.

Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT.

Background And Purpose: Robustness against input data perturbations is essential for deploying deep-learning models in clinical practice. Adversarial attacks involve subtle, voxel-level manipulations of scans to increase deep-learning models' prediction errors. Testing deep-learning model performance on examples of adversarial images provides a measure of robustness, and including adversarial images in the training set can improve the model's robustness.

CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation.

Introduction: T cell activation requires T cell receptor (TCR) engagement by its specific ligand. This interaction initiates a series of proximal events including tyrosine phosphorylation of the CD3 and TCRζ chains, recruitment, and activation of the protein tyrosine kinases Lck and ZAP70, followed by recruitment of adapter and signaling proteins. CD28 co-stimulation is also required to generate a functional immune response.

A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence.

Intracerebral hemorrhage (ICH) and perihematomal edema (PHE) are key imaging markers of primary and secondary brain injury in hemorrhagic stroke. Accurate segmentation and quantification of ICH and PHE can help with prognostication and guide treatment planning. In this study, we combined Swin-Unet Transformers with nnU-NETv2 convolutional network for segmentation of ICH and PHE on non-contrast head CTs.

Machine Learning Models for 3-Month Outcome Prediction Using Radiomics of Intracerebral Hemorrhage and Perihematomal Edema from Admission Head Computed Tomography (CT).

: Intracerebral hemorrhages (ICH) and perihematomal edema (PHE) are respective imaging markers of primary and secondary brain injury in hemorrhagic stroke. In this study, we explored the potential added value of PHE radiomic features for prognostication in ICH patients. : Using a multicentric trial cohort of acute supratentorial ICH ( = 852) patients, we extracted radiomic features from ICH and PHE lesions on admission non-contrast head CTs.

Efficacy of Prophylactic Antibiotics in COPD: A Systematic Review.

: Chronic obstructive pulmonary disease (COPD) is a global health problem and the third leading contributor to mortality worldwide. This systematic review aims to summarize the results of previous studies tackling the question of the efficacy of long-term prophylaxis of antibiotics in COPD patients, with particular regard to exacerbation rate, time to first exacerbation, health status, airway bacterial load, inflammatory markers, cell counts in sputum samples, and potential adverse events. : Four studies found significant improvement in the exacerbation rate in patients receiving antibiotic intervention.

Validation of AI-driven measurements for hip morphology assessment.

Rationale And Objectives: Accurate assessment of hip morphology is crucial for the diagnosis and management of hip pathologies. Traditional manual measurements are prone to mistakes and inter- and intra-reader variability. Artificial intelligence (AI) could mitigate such issues by providing accurate and reproducible measurements.

Erratum: Lipid nanoparticle encapsulation of a Delta spike-CD40L DNA vaccine improves effectiveness against Omicron challenge in Syrian hamsters.

[This corrects the article DOI: 10.1016/j.omtm.

Hyperglycemia causes differential change in macrophage population in the lacrimal gland, conjunctiva and cornea.

Background: Due to its location, the ocular surface is exposed to environmental microbes. Innate immune cells including macrophages are first line defense against infections. exposure to high glucose as well as diabetes-associated hyperglycemia has been shown to affect innate immune cell function and population.

Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children.

Background: The National Institutes of Health (NIH) Toolbox Cognition Battery is increasingly being used as a standardized test to examine cognitive functioning in multicentric studies. This study examines the associations between the NIH Toolbox Cognition Battery composite scores with neuroimaging metrics using data from the Adolescent Brain Cognitive Development (ABCD) study to elucidate the neurobiological and neuroanatomical correlates of these cognitive scores.

Methods: Neuroimaging data from 5290 children (mean age 9.

Advancements and Applications of Conjugated Polyelectrolytes and Conjugated Oligoelectrolytes in Bioanalytical and Electrochemical Contexts.

In the past decade, conjugated oligoelectrolytes (COEs) and conjugated polyelectrolytes (CPEs) have emerged at the forefront of active materials in bioanalytical and electrochemical settings due to their unique electronic and ionic properties. These materials possess π-conjugated backbones with ionic functionalities at the ends of their side chains, granting them water solubility and facilitating their processability, exploration, and applications in aqueous environments. In this perspective, the basis for evaluating their figures of merit in selected bioanalytical and electrochemical contexts will be provided and contextualized.

Adolescent transition preparation around the COVID-19 pandemic: A cross-sectional study.

Objective: To compare preparation for transition in adolescents in the United States prior to and during the COVID-19 pandemic.

Study Design: We used data from the 2019 and 2021 National Survey of Children's Health to compare transition preparation before and after the COVID-19 pandemic among adolescents who had a medical care visit within the preceding year, controlled for relevant potential confounders. The association of demographic factors and survey year with a composite measure of adequate transition preparation was evaluated using univariable analysis and multivariable logistic regression.

Progressive anosmia revealing olfactory cleft actinomycosis: A CARE case report.

Introduction: Progressive anosmia, unlike sudden-onset viral or traumatic anosmia, requires endoscopic screening for nasal polyps. In the absence of polyposis, radiological work-up should diagnose and treat any curable pathology. Here, we report the case of a patient treated for olfactory cleft actinomycosis.

L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.

Introduction: Endometrial cancer is the most common malignancy of the female reproductive system in the United States. is a versatile, nutrient-dense, low-calorie vegetable that contains various bioactive metabolites that have shown a variety of biologic functions beneficial to health. The metabolites from extracts or extracts exhibit significant anti-tumorigenic activity in some pre-clinical models of cancer.