Publications by authors named "Tramy Ngouanesavanh"

We reported previously that Cryptosporidium parvum was able to induce intestinal tumors in severe combined immunodeficiency (SCID) mice treated with corticoids. To further characterize this Cryptosporidium-induced cell transformation, SCID mice treated with dexamethasone were challenged with C. parvum oocysts, and euthanatized sequentially after infection for histologic examination.

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Background: Cryptosporidiosis represents a major public health problem. This infection has been reported worldwide as a frequent cause of diarrhoea. Particularly, it remains a clinically significant opportunistic infection among immunocompromised patients, causing potentially life-threatening diarrhoea in HIV-infected persons.

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Synopsis of recent research by authors named "Tramy Ngouanesavanh"

  • - Tramy Ngouanesavanh's research primarily focuses on the role of
  • Cryptosporidium parvum
  • in gastrointestinal diseases, particularly its potential to induce neoplasia in immunocompromised hosts, such as SCID mice, highlighting the correlation between infection intensity and the severity of induced lesions.
  • - The studies emphasize
  • Cryptosporidium
  • as not only a significant opportunistic pathogen in immunocompromised individuals but also its potential association with severe health outcomes, including the development of colic adenocarcinoma.
  • - Ngouanesavanh's work also explores the
  • population genetics
  • of
  • Cryptosporidium
  • , providing insights into the genetic diversity and clonality of isolates from different regions, including France, Haiti, and Venezuela.