[Advanced ectopic pregnancy--clinical management].

Advanced ectopic pregnancy - clinical management. In case of vaginal bleeding and diffuse abdominal pain you have to include the diagnose of (rare) advanced ectopic pregnancy. Even with ultrasound technique in some of the cases you need further examinations to be sure with your diagnose.

[Angiosarcoma of the breast after conservatively operated breast carcinoma--a sequela of adjuvant radiotherapy?].

Angiosarcoma represents only 2.4% of soft tissue malignancies. Primary angiosarcoma of the breast is also a rare neoplasm.

Two human breast cancer cell lines showing decreasing telomeric repeat length during early in vitro passaging.

Specific DNA repeats serve as a molecular protection shield at the telomeric ends of mammalian chromosomes. The absence of telomerase activity leads to a gradual decrease of telomeric repeat length in normal somatic cells. In contrast, immortalized cells from malignant tumors are usually thought to re-express telomerase to overcome a self-limited growth.

Adjuvant randomized trials of doxorubicin/cyclophosphamide versus doxorubicin/cyclophosphamide/tamoxifen and CMF chemotherapy versus tamoxifen in women with node-positive breast cancer.

Purpose: We report two randomized trials of adjuvant systemic therapy in 747 patients < or = 65 years of age with histologically proven node-positive breast cancer.

Patients And Methods: Patients were selected for the two trials on the basis of lymph node and hormone receptor status. The only stratification was based on the treating institution.

Effects of tamoxifen on human breast cancer cells in vitro.

Long-term treatment of the estrogen sensitive human breast cancer cell line EFM-19 with the antiestrogenic compound Tamoxifen resulted in a variant line EFM-19 T, which was stimulated by Tamoxifen. Estrogen receptor analysis by radioligand assay (charcoal method), revealed a 2.5 fold higher receptor concentration in EF-19 T cells than in the parental EFM-19 cell-line.

[Subjective stress of adjuvant chemotherapy in breast cancer patients].

50 patients, suffering from carcinoma of the breast pT1-3 with concomitant metastatic affection of the lymph nodes with no evidence of distant metastases, and who received adjuvant chemotherapy (either CMF od AC/EC) were examined. Somatic and psychic interferences, the feeling of well-being and general condition, as well as a critical estimation of the clinical situation were assessed. Besides nausea and vomiting, and still prior to hair fall out, chemotherapy activated the memory of the carcinoma.

[Diagnostic predictive value of C-reactive protein and expectant management of patients with premature rupture of the membranes].

To evaluate the predictive diagnostic value of CRP in a wait-and-see management of PROM 110 courses of labour and childbed with 114 babies were investigated with respect to both complications of mother and newborn. Complications during childbed could only be seen in 2.7%, 3.

[Secretory breast cancer. A special morphologic entity, especially in children and young females].

We are reporting a rare case of secretory breast cancer with axillary node involvement in a 16-year-old patient. Symptomatic systemic spread occured unusually early during adjuvant chemotherapy, suggesting primary resistance of the tumour to chemotherapy. We are unaware of any such case reports published world wide.

[Locoregional breast cancer recurrence. Treatment following exclusively local therapy].

In 58 out of 515 patients with a primary carcinoma of the breast there was local-regional recurrence. Treatment consisted in generous excision and local radiation (50-60 Gy). After a mean observation period of 65.

[Importance of clinically prognostic factors in the treatment of advanced ovarian carcinoma].

25 patients with stage III and IV ovarian carcinoma were treated with radical surgery and postoperative chemotherapy. Analysis of the disease-free intervals and the survival rates indicated significant differences related to the stage of the disease. Furthermore patients with minimal residual disease (tumor mass less than 2 cm in diameter) had a far better prognosis than patients with extensive residual disease (greater than 3 cm).

[5 years' experiences with adjuvant chemotherapy in primary breast cancer].

In 515 patients with primary carcinoma of the breast T1a-3aN1a-bM0, the authors conducted simple mastectomy with radical lymphonodectomy of the axilla from 1976 onwards to the time of reporting. In 190 patients with affected lymph nodes, assisting chemotherapy was effected with a combination of three drugs, namely, trofosfamide, methotrexate and 5-fluoro-uracil for a period of 12 months postoperatively. Patients whose lymph nodes remained free were not subjected to follow-up treatment.

In vitro growth promotion of human mammary carcinoma cells by steroid hormones, tamoxifen, and prolactin.

Individually different growth responses of 10 cell lines newly derived from metastasizing mammary carcinomas were determined by cell counts in experimental incubations with the steroid hormones 17 beta-estradiol, progesterone, testosterone, hydrocortisone (cortisol), the antiestrogenic compound tamoxifen, or prolactin. Of 7 cell lines derived from ductal carcinomas, 5 were stimulated by prolactin. The growth of 4 of 7 cell lines established from the tumors of postmenopausal or ovariectomized patients was enhanced by doses of testosterone, which are in the range of the physiologic serum level.

9. Steroid receptors. Correlation of estrogen and progesterone receptor status with ultrastructural differentiation in breast tumors.

The interrelationships of ultrastructural and biochemical parameters have been studied in a multivariate analysis of 139 cases of invasive breast carcinoma. There was no relationship between the histologic subclassification and distribution of estrogen and progesterone receptors. However, significant correlations could be found between receptor status and certain ultrastructural features of the tumor cells.

[Post-operative complications following Caesarean section. A comparative study of the years 1957-1958 and 1977-1978].

104 Caesarean sections of the Obstetric Department of the University in Hamburg-Eppendorf of the years 1957-1958 were compared with 399 Caesarean sections of the years 1977-1978 in a retrospective study. An attempt was made to correlate the post-operative complications with possible causes. There was a marked rise in wound infections, endometritis, post-operative pyrexia and a decrease of thromboembolic complications and retained lochia.

[Ancillary chemotherapy with trofosfamid, methotrexate and fluoro-uracil in cancer of the breast (author's transl)].

The results of adjuvant chemotherapy in the treatment of primary cancer of the breast is reported. During 44 months 401 patients were admitted to the prospective study. All patients with a cancer of the breast T1a-3a, N0-1b, M0 were operated by modification of the Patey procedure.

The problem of nonresponding estrogen receptor-positive patients with advanced breast cancer.

Patients with advanced breast cancer and low or poor concentration of estrogen receptors in tumor biopsies have little chance of responding to endocrine therapy. This problem was seen in a group of nonresponding estrogen receptor-positive (ER+) patients. Some comments on possible explanations for this phenomenon are made and suggestions to overcome it are given.

Estrogen receptor status and response to polychemotherapy in advanced breast cancer.

In a retrospective study, response to systemic polychemotherapy was analyzed in 72 female patients having advanced breast cancer and correlated with estrogen receptor (ER) status. Estrogen receptors were analyzed by agar-gel electrophoresis or uptake competition technique in tumor biopsy specimens derived from the primary tumor or from metastases. The borderline between positive and negative ER values was declared to be 20 fmol/mg tissue protein.

[The clinical significance of hormone receptors in the treatment of breast cancer].

The assay of steroid receptors in tumor tissue has been shown to be a useful tool to evaluate the response of disseminated breast cancer to endocrine therapy. Principle and problems of this assay are outlined. An objective response of estrogen-receptor positive tumors to endocrine treatment can be achieved in about 60%.

On the function of hormone receptors in the action of steroidal alkylating agents.

Steroidal alkylating agents are supposed to bind to steroid hormone receptors in target tissues. By this interaction the steroid portion might act as a carrier for the alkylating group. Three steroidal agents (phenesterin, estradiol mustard, dehydroepiandrosterone mustard) were tested for their capacity to combine with estrogen and androgen receptors in normal and malignant target tissues.

Progesterone in the uterus. VIII. Uptake of corticosterone and incorporation of progesterone under concurrent injection of corticosterone into rat uterus.

A study of the subcellular distribution of radioactivity in rat uterus after injection of labelled corticosterone showed that the radioactivity was observed in all fractions from 5 min. to 120 min. A maximum uptake was observed 10 min.