Publications by authors named "Trairong Chokwassanasakulkit"
Traditionally, antiviral drugs target viral enzymes and or structural proteins, identified through large drug screens or rational drug design. The screening, chemical optimisation, small animal toxicity studies and clinical trials mean time to market is long for a new compound, and in the event of a novel virus or pandemic, weeks, and months matter. Small interfering RNAs (siRNAs) as a gene silencing platform is an alluring alternative.
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- Merkel cell polyomavirus (MCPyV) is a key factor in causing Merkel cell carcinoma (MCC), a deadly skin cancer with a low survival rate and high recurrence.
- Current treatments for MCC are often ineffective, especially for metastatic cases, creating a pressing need for new therapeutic options.
- Gene-targeted therapies like siRNA and CRISPR/Cas hold potential for MCC treatment, but more research and clinical trials are needed to translate these strategies into effective solutions.