Diastereoselective palladium-catalyzed alpha-arylation of 4-substituted cyclohexyl esters.

A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu3P)PdBr]2 providing products in up to 37:1 dr.