Publications by authors named "Tracy C Yang"
Background: The bioeffects of space radiation on organisms outside of the environment of Earth's magnetosphere are a concern for long-duration exploration spaceflights. Potential mutagenic effects from space radiation exposure result from direct DNA damage or indirectly from the production of reactive oxygen species (ROS).
Hypotheses: 1) Transepithelial electrical resistance (TER) measurements in cell culture monolayers may be used as a model system for detecting cell damage produced by exposure to simulated space radiation and for testing potential chemoprotective agents; 2) biomarkers of exposure that quantitate indirect radiation effects may allow prediction of cellular DNA damage; and 3) a multiple agent, chemoprevention cocktail may reduce the bioeffects of simulated space radiation.
Article Synopsis
- This paper investigates the effects of radiation exposure on residents of two villages near the Semipalatinsk nuclear testing site, Chekoman and Dolon.
- Chekoman is relatively less affected by radiation than Dolon, which is about 100 km away, but both communities have similar lifestyles.
- Analysis of chromosome aberrations in lymphocytes using fluorescence in situ hybridization revealed that residents of Dolon had a significantly higher average frequency of stable translocations, indicating a radiation dose of approximately 180 mSv.
Chromosome aberrations were investigated in human lymphocytes after in vitro exposure to 1H-, 3He-, 12C-, 40Ar-, 28Si-, 56Fe-, or 197Au-ion beams, with LET ranging from approximately 0.4-1393 keV/microm in the dose range of 0.075-3 Gy.
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