Cybernetics and consciousness.

This paper is a review of hypotheses of consciousness which arose from application of the theory of information and regulation and the cybernetic theory of mathematical machines in medicine. The author presents these hypotheses on the examples of his own works.

[Numeric description of circadian rhythm of TSH in patients with cold tumors of the thyroid gland before and after surgery].

Circadian rhythm of TSH was analyzed in patients with cold tumors of the thyroid before and after surgical removal of the tumors and in control subjects. By using special computer program BIOR based on harmonic and regression analysis, designed for verifying and comparing various biorhythms, significant differences were found between TSH biorhythms in patients with cold thyroid tumors before and after the operation.

[Changes in synaptic potentials and axonal delays as factors causing epileptic instability of neuronal networks].

Synaptic weights, axonal delays and excitability thresholds are three basic parameters influencing the function of neuronal network as a dynamic system. Changes of the general level of the signal flow, without changes in relation between excitatory and inhibitory connections can cause pathologic oscillations in the network. The conductivity in neuronal nets depends on electrochemical processes and may be influenced by the pH-status, ion concentrations, among other parameters.

[Study of the mechanisms of the development of epileptic activity in neuronal networks using a simulation model].

The occurrence of synchronous, self-sustaining seizure activity is one of the basic mechanisms underlying epileptic attacks. Using a mathematical model of neuronal network in various simulation experiments carried out in digital computer the conditions were studied of the development of pathological epileptic activity and the conditions of the parameters of this network affecting its stable function. After exceeding of a threshold value in the relation between the weights of the stimulating and inhibiting synapses an unstable epileptic response appears.

Kindled seizures: anticonvulsant drugs and agents.

Repeated administration of an initially subconvulsive electrical stimulation results in a progressive intensification of the seizure activity, which is known as a kindling phenomenon. The stability of the kindling model of seizures is particularly useful for evaluation of the action of anticonvulsant drugs. In the present study the action of different substances on kindled seizures is reviewed.

[Importance of EEG studies in the assessment of hearing and equilibrium disorders of central origin].

In a group of 52 patients with hearing and equilibrium disturbances of central origin EEG was done. The obtained EEG findings were correlated with: a) main clinical manifestations of the type of function loss or stimulation, and b) disturbances of behavioural perception, that is specific signs of disturbed perception and non-specific extraperceptive signs. Disturbed hearing, independently of the side of lesion, was accompanied by focal disturbances of electrogenesis in left temporal leads.