Publications by authors named "Tra L Kieu"
Article Synopsis
- Cardiomyopathy is a progressive heart disease linked to impaired function, with genotoxic cancer therapies recognized as key risk factors, though natural causes remain uncertain.
- In a study, researchers engineered mice to lack a DNA repair gene (Ercc1) in heart muscle, resulting in severe heart issues like ventricular dilation and systolic dysfunction by 7 months of age.
- The findings suggest that internal DNA damage leads to cardiac problems through the activation of the p53 protein and increased oxidative stress, ultimately causing heart cell death and related diseases.
We aimed to determine if an adolescent patient presenting with neurological impairment has xeroderma pigmentosum (XP). For this purpose, whole-exome sequencing was performed to assess mutations in genes. Dermal fibroblasts were established from a skin biopsy and XPA expression determined by immunoblotting.
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