Publications by authors named "Toyomi Sato"
Article Synopsis
- The study aimed to compare the diagnostic effectiveness of virtual monoenergetic imaging (VMI), computed tomography (CT), and magnetic resonance imaging (MRI) in diagnosing endometrial cancer (EC).
- It involved a retrospective analysis of 45 EC patients, focusing on the contrast-to-noise ratio (CNR) and the ability to detect myometrial invasion, cervical invasion, and lymph node metastasis.
- Results indicated that VMI had higher sensitivity for detecting myometrial invasion, while C-CT showed superior sensitivity for cervical invasion, suggesting a potential advantage in using VMI alongside C-CT for preoperative staging of EC.
Background: The prognosis of gynecological malignancies has improved with the recent advent of molecularly targeted drugs and immune checkpoint inhibitors. However, these drugs are expensive and contribute to the increasing costs of medical care.
Methods: The Japanese Clinical Oncology Group (JCOG) Health Economics Committee conducted a questionnaire survey of JCOG-affiliated facilities from July 2021 to June 2022 to assess the prevalence of high-cost regimens.
Article Synopsis
- Intraperitoneal chemotherapy may reduce mortality in patients with advanced epithelial ovarian cancer but is not commonly used, prompting the iPocc trial to evaluate its effectiveness.
- The trial involved 655 women with newly diagnosed cancer, comparing the effects of intravenous carboplatin alone to a combination of intravenous and intraperitoneal carboplatin along with paclitaxel.
- Results showed that the group receiving intraperitoneal carboplatin had a longer progression-free survival (23.5 months) compared to the intravenous group (20.7 months), but faced higher rates of catheter-related adverse events.
Impact of pre-brachytherapy magnetic resonance imaging on dose-volume histogram of locally advanced cervical cancer patients treated with radiotherapy including high-dose-rate brachytherapy.
J Contemp Brachytherapy
February 2021
Purpose: This study investigated the suitability of brachytherapy technique selection based on pre-brachytherapy magnetic resonance imaging (MRI) findings in cervical cancer by evaluating dose-volume histogram parameters.
Material And Methods: We retrospectively evaluated data from 61 patients with cervical cancer who underwent pre-brachytherapy MRI within 7 days before their first high-dose-rate brachytherapy treatment, selected according to pre-brachytherapy MRI findings. Combined intracavitary brachytherapy with interstitial techniques (IC/ISBT) or interstitial brachytherapy (ISBT) were favored treatments for poor-responding tumors after concurrent chemoradiotherapy, asymmetrical tumors, bulky parametrial extensions, bulky primary disease, and extensive paravaginal or distal vaginal involvement.
Purpose: To compare the prevalence of enlarged ovarian and intrapelvic parasitic arteries to the gravid uterus between cases of placenta accreta spectrum (PAS) and those with normal placentation using unenhanced magnetic resonance (MR) angiography.
Methods: Unenhanced time-of-flight MR angiography was performed in 12 consecutive women with PAS (mean age, 34 years; range, 23-42 years) and 24 women with normal placentation (mean age, 31 years; range, 24-42 years) in their third trimester and reviewed by two independent observers. The consensus reading served as the reference standard.
Vaginal creation is the standard treatment for Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Although non-surgical method is recommended as a first-line treatment in the American College of Obstetricians and Gynecologists guidelines for gynecological practice, it is not commonly performed in Japan. At our hospital, vaginal dilation using uterine cervical dilators (Hegar's dilator) is performed for patients with MRKH syndrome.
View Article and Find Full Text PDFEmerging evidence suggests that DNAM-1 (CD226) play an important role in the recognition of tumor cells and their lysis by cytotoxic T lymphocytes (CTL) and NK cells. Although the DNAM-1 ligand CD155 is ubiquitously expressed in various tissues, many human tumors significantly upregulate the expression of CD155; DNAM-1 on CTL and NK cells may be involved in tumor immunity. However, unlike those in mice, human tissues also express soluble isoforms of CD155 (sCD155) that lack the transmembrane region.
View Article and Find Full Text PDFPurpose: To evaluate the utility of measuring the volumes of areas of high signal intensity on T(2)-weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer.
Materials And Methods: From our departmental database, we identified 109 patients with cervical cancer who underwent MR imaging before irradiation and just before or just after completion of radiation therapy from 1994 to 2007. We included 46 of the 109 patients in this study, 5 patients with local recurrence and 41 patients who were free of disease for more than 2 years.