Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression.

Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and zuranolone, the first US Food and Drug Administration-approved drugs for postpartum depression, signify a critical advancement in addressing the unmet needs of a vulnerable patient population.

Hybrid-resolution facial and dental scanning: a cost-effective approach to utilizing 3D facial data in anterior dental implant restoration.

As digital technology becomes more prevalent in the practice of dental medicine, methods to fully replace 2-dimensional photography and analog devices such as the facebow are still in their infancy. As more practices adopt 3-dimensional (3D) intraoral scanners, effective digital communication of the relationships between the teeth and the face becomes essential. With the high cost of intraoral scanners, the additional expense of a face scanner is not a feasible investment for many practices.

Autotransplantation: a lost art worthy of revival in the era of implants.

While synthetic implants represent a significant contribution to the advancement of dental medicine, they are associated with high costs, potential complications, and time delays. With autotransplantation, the patient is both donor and recipient of a living tooth; in the ideal case, this procedure transfers a healthy, nonfunctional tooth to a functional position. The aim of this article is to review the literature surrounding autotransplantation and present a successful case with the hope of increasing awareness of this approach to tooth replacement.

Regenerative rehabilitation: exploring the synergistic effects of rehabilitation and implantation of a bio-functional scaffold in enhancing nerve regeneration.

Clinically, rehabilitation is one of the most common treatment options for traumatic injuries. Despite that, recovery remains suboptimal and recent breakthroughs in regenerative approaches may potentially improve clinical outcomes. To date, there have been numerous studies on the utilization of either rehabilitative or regenerative strategies for traumatic injury treatment.

Cognitive Reserve and Postoperative Delirium in Older Adults.

Objectives: To examine the role of cognitive reserve in reducing delirium incidence and severity in older adults undergoing surgery.

Design: Prospective cohort study.

Setting: Hospital.

Objective cardiac markers and cerebrovascular lesions in Indian seniors.

Cardiovascular risk factors are implicated in cerebrovascular disease, resulting in cognitive impairment. This study investigated the relationship between objective cardiac markers and cerebral changes in older Indian adults with and without dementia. Dementia patients with major electrocardiographic (EKG) abnormalities were 8.

Walking while talking and falls in aging.

Background: While divided attention tasks are recognized as predictors of falls in older adults, a comprehensive examination of this association is lacking.

Objective: We examined the validity of a 'walking while talking' (WWT) task for predicting falls.

Methods: We studied the associations of 8 selected gait markers measured during WWT (individually as well as domains derived by factor analysis) with incident falls in 646 adults (mean age 79.

Detection of abnormal muscle activations during walking following spinal cord injury (SCI).

In order to identify optimal rehabilitation strategies for spinal cord injury (SCI) participants, assessment of impaired walking is required to detect, monitor and quantify movement disorders. In the proposed assessment, ten healthy and seven SCI participants were recruited to perform an over-ground walking test at slow walking speeds. SCI participants were given assistance from physiotherapists, if required, while they were walking.

Synchronized walking coordination for impact-less footpad contact of an overground gait rehabilitation system: NaTUre-gaits.

Due to the labor-intensiveness and the shortage of therapists in the application of most forms of manually assisted gait training in neuro-rehabilitation, robotics rehabilitation gait systems have been developed to contribute in such fields of neuro-rehabilitation. This paper presents an overground gait rehabilitation robot, which consists of a pair of robotic orthosis (RO) connected to pelvic arm (PA) and mounted on a mobile platform (MP). As the robotic orthosis (RO) is connected to pelvic arm (PA), the compensation between the two modules should be considered.

Household density and obesity in young black and white adults.

Racial and ethnic disparities in obesity persist despite a narrowing in obesity risk associated with socioeconomic status. The household environment has been shown to be important in understanding obesity-promoting behaviors in diverse populations. Our current study was designed to examine the relationship between household density and obesity in young Black and White adults aged 18-30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort.

Recovery and regeneration after spinal cord injury: a review and summary of recent literature.

Introduction: Spinal cord injury (SCI) often results in significant neurologic dysfunction and disability. An annual incidence of 15 to 40 traumatic SCI cases per million population has been reported worldwide, and a conservative estimate for Singapore would be 23 cases per million. With continued improvements in medical care, an increasing prevalence of SCI patients is expected, with corresponding need for comprehensive rehabilitation services led by specialist rehabilitation physicians.

Botulinum toxin type A for refractory neurogenic detrusor overactivity in spinal cord injured patients in Singapore.

Introduction: Managing neurogenic detrusor overactivity (NDO) successfully in spinal cord-injured patients is a challenge. The aims of preserving kidney function by achieving safe bladder pressures with anticholinergic medication often leave a significant proportion of patients with side effects. Botulinum toxin type A has been shown to be a promising alternative.

Pain during in-patient rehabilitation after traumatic spinal cord injury.

In this prospective study, we surveyed the pain experience of 40 participants during the in-patient rehabilitation period following traumatic spinal cord injury (SCI). Twenty-eight patients (70% of the study population) had musculoskeletal (MS) pain or neuropathic (NP) pain. Pain responded positively to physical therapy and analgesics.

Vital capacity in tetraplegics twenty years and beyond.

Objectives: To observe the trends in vital capacity (VC) over time in tetraplegics 20 years and more after injury, the effects of age at injury, severity of injury and gender on this trend.

Methods: The medical records of all spinal cord injured persons admitted to a regional spinal injury center from January 1960 to December 1996 were reviewed. Fifty-seven patients had documented post-rehabilitation VC (mean 1.

Clinical characteristics and functional outcome of stroke patients 75 years old and older.

Objective: To examine the demographic and clinical characteristics of stroke patients 75 years old and older admitted for rehabilitation, to study medical complications that occurred during rehabilitation, and to document functional outcome and possible factors influencing outcome.

Design And Setting: A case series of 59 consecutive inpatients admitted to a rehabilitation facility with confirmed strokes over a 2-year period.

Measures: Patients were selected by rehabilitation physicians for admission into the rehabilitation program.

The alien hand sign--case report and review of the literature.

The alien hand sign refers to a group of signs which include a feeling that the hand is foreign together with autonomous activity, as if the hand is driven by an external agent. These features are commonly associated with frontal and callosal lesions. We report the alien hand sign in a man with left medial cortical infarct, presenting with autonomous grasping and groping with his right upper limb, denial of ownership of his limb, and dissociative phenomena including self restriction and intermanual conflict.

Central cord syndrome: functional outcome after rehabilitation.

Seventy-three spinal cord injured patients with central cord syndrome who had undergone inpatient rehabilitation, were studied retrospectively with regard to their demographic, neurologic and functional characteristics. There were 67 males and six females with a mean age of 53.5 years.

The neurogenic bladder in spinal cord injury--pattern and management.

This study describes the various types of neurogenic bladder in spinal cord injury in relation to the level of lesion, defines the aims of bladder management, and discusses the importance of highly individualised management strategies and long-term follow-up. Urodynamic studies were done on 47 new patients with traumatic spinal cord injury when they had return of reflexic bladder activity. This study was conducted over a one-year period.

Prolonged fever and heterotopic ossification in a C4 tetraplegic patient. Case report.

Prolonged fever is an uncommon diagnostic problem in a spinal cord injury patient. The underlying causes include recurrent infections, thromboembolic phenomena and central fever. We report a case of heterotopic ossification in a traumatic C4 tetraplegic patient presenting as prolonged fever of 3 months' duration.

Randomised study comparing imipenem/cilastatin to ceftriaxone plus gentamicin in cancer chemotherapy-induced neutropenic fever.

Prompt initiation of empiric antibiotic therapy is the cornerstone in the therapy of chemotherapy-induced neutropenic sepsis in cancer patients. Ceftriaxone plus gentamicin (ceftriaxone/gentamicin) is the most widely used combination of empiric antibiotics in the Department of Medical Oncology, Singapore General Hospital. However, imipenem/cilastatin has been shown to be a practical alternative.