Novel - and - fusions in pediatric leukemia with normal karyotype.

Background: Many cases of acute lymphoblastic leukemia (ALL) carry visible acquired chromosomal changes of pathogenetic, diagnostic, and prognostic importance. Nevertheless, from one-fourth to half of newly diagnosed ALL patients have no visible chromosomal changes detectable by G-banding analysis at diagnosis. The introduction of powerful molecular methodologies has shown that many karyotypically normal ALLs carry clinically important submicroscopic aberrations.

Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.

Background: Hepatic sinusoidal obstruction syndrome (SOS) during treatment of childhood acute lymphoblastic leukemia (ALL) has mainly been associated with 6-thioguanine. The occurrence of several SOS cases after the introduction of extended pegylated asparaginase (PEG-asparaginase) therapy in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol led us to hypothesize that PEG-asparaginase, combined with other drugs, may trigger SOS during 6-thioguanine-free maintenance therapy.

Procedure: In children with ALL treated in Denmark according to the NOPHO ALL2008 protocol, we investigated the risk of SOS during methotrexate (MTX)/6-mercaptopurine (6MP) maintenance therapy that included PEG-asparaginase until week 33 (randomized to two- vs.

The effect of coffee consumption on serum total cholesterol in the Sami and Norwegian populations.

Objective: To assess coffee consumption in the Sami and Norwegian populations and to investigate the impact of unfiltered boiled coffee consumption on serum cholesterol concentrations.

Design: A cross-sectional study. Information was collected by self-administrated questionnaires and total serum cholesterol was analysed.

Ethnic differences in the prevalence of general and central obesity among the Sami and Norwegian populations: the SAMINOR study.

Aims: To estimate the prevalence of general (body mass index) and central (waist circumference and waist/hip ratio) obesity in an area with a mixed Sami and Norwegian population.

Methods: A cross-sectional population-based study carried out in 2003- 2004, the SAMINOR study. The attendance rate was 60.

Sami speakers are less satisfied with general practitioners' services.

Objectives: The government's Action Plan for Health and Social Services states as a goal that the Sami population's encounter with health and social services should be just as good as what the rest of the population experiences. The goal of this study is to investigate patient satisfaction with the municipal GP service in areas with both a Sami and Norwegian population.

Study Design: A cross-sectional population study using questionnaires.

Population based study of health and living conditions in areas with both Sámi and Norwegian populations--the SAMINOR study.

Objectives: The overall aim of the SAMINOR project was to study health and diseases in relation to living conditions among the Sámi population and to compare these with the Norwegian population in the same area. This article provides an overview of the background of the study and a description of the methods employed for the data collection. We give sample characteristics and elaborate on different definitions of ethnicity.

[The monolingual Sámi population is less satisfied with the primary health care].

Background: The purpose of this study was to describe patient satisfaction in general practice among the Sámi monolingual population, as compared with the Norwegian population.

Material And Methods: The data was collected in 2002-2004 through a health survey in communities with Sámi and Norwegian population, SAMINOR. The analyses included 15,612 men and women between 36 and 79 years, with a response rate of 60.