Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers.

: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. : Eighty healthy overweight or obese office workers aged 40-67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed.