RRDetection: Respiration Rate Estimation Using Earbuds During Physical Activities.

In modern times, earbuds have become both popular and essential accessories for people to use with a wide range of devices in their everyday lives. Moreover, the respiration rate is a crucial vital sign that is sensitive to various pathological conditions. Many earbuds now come equipped with multiple sensing capabilities, including inertial and acoustic sensors.

Subconjunctival Delivery of Sorafenib-Tosylate-Loaded Cubosomes for Facilitated Diabetic Retinopathy Treatment: Formulation Development, Evaluation, Pharmacokinetic and Pharmacodynamic (PKPD) Studies.

Diabetic retinopathy (DR) is a microvascular complication associated with vascular endothelial growth factor (VEGF) overexpression. Therapeutic delivery to the retina is a challenging phenomenon due to ocular biological barriers. Sorafenib tosylate (ST) is a lipophilic drug with low molecular weight, making it ineffective at bypassing the blood-retinal barrier (BRB) to reach the target site.

Role of Endogenous Lipopolysaccharides in Neurological Disorders.

Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-negative bacteria. A growing body of evidence reveals that alterations in the bacterial composition of the intestinal microbiota (gut dysbiosis) disrupt host immune homeostasis and the intestinal barrier function. Microbial dysbiosis leads to a proinflammatory milieu and systemic endotoxemia, which contribute to the development of neurodegenerative diseases and metabolic disorders.

Detecting Physiological Responses Using Multimodal Earbud Sensors.

Continuous stress exposure negatively impacts mental and physical well-being. Physiological arousal due to stress affects heartbeat frequency, changes breathing pattern and peripheral temperature, among several other bodily responses. Traditionally stress detection is performed by collecting signals such as electrocardiogram (ECG), respiration, and skin conductance response using uncomfortable sensors such as a chestband.

A Novel Multi-Centroid Template Matching Algorithm and Its Application to Cough Detection.

Cough is a major symptom of respiratory-related diseases. There exists a tremendous amount of work in detecting coughs from audio but there has been no effort to identify coughs from solely inertial measurement unit (IMU). Coughing causes motion across the whole body and especially on the neck and head.

Device Invariant Deep Neural Networks for Pulmonary Audio Event Detection Across Mobile and Wearable Devices.

Mobile and wearable devices are being increasingly used for developing audio based machine learning models to infer pulmonary health, exacerbation and activity. A major challenge to widespread usage and deployment of such pulmonary health monitoring audio models is to maintain accuracy and robustness across a variety of commodity devices, due to the effect of device heterogeneity. Because of this phenomenon, pulmonary audio models developed with data from one type of device perform poorly when deployed on another type of device.

RRMonitor: A Resource-Aware End-to-End System for Continuous Monitoring of Respiration Rate Using Earbuds.

Respiration rate is considered as a critical vital sign, and daily monitoring of respiration rate could provide helpful information about any acute condition in the human body. While researchers have been exploring mobile devices for respiration rate monitoring, passive and continuous monitoring is still not feasible due to many usability challenges (e.g.

Strength evolution laws in curing of solvent-welded polymers.

This paper reports the scaling laws to describe the time-evolution behavior of solvent-mediated strength at the interface between two identical thermoplastic polymers below the glass-transition temperature. Our results suggest that the evolution scales as sqrt[t], where t is the curing time. It depends on the time evolution of interfacial stiffness and toughness, each of which scales as sqrt[t].

Correlation of Subclinical Hypothyroidism With Polycystic Ovary Syndrome (PCOS).

Aim The correlation of subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) is a still insufficiently explored entity. The aim of this study was to determine the correlation between SCH and PCOS along with the impact of SCH on metabolic and hormonal parameters in women with PCOS. Methodology This cross-sectional study was conducted at the Gynecology Outpatient Department of Ziauddin Hospital Kemari, Karachi, Pakistan, from June 2019 to December 2019.

Comparative Evaluation of the Embrasure Wire versus Arch Bar Maxillomandibular Fixation in the Management of Mandibular Fractures: Are Arch Bars Replaceable?

The aim of this prospective study was to appraise the role of embrasure wiring in the treatment of mandibular fractures over the arch bar as adjunctive techniques of maxillomandibular fixation (MMF). This study was conducted on 40 patients who were surgically treated for mandibular fractures with accessory use of MMF (embrasure: group A vs. arch bars: group B).