Publications by authors named "Touichi Kawabe"
Article Synopsis
- The REGAIN trial found that spinal and general anesthesia provide similar outcomes regarding ambulation and survival after hip fracture surgery.
- In a secondary analysis, researchers compared pain levels, analgesic use, and patient satisfaction between the two anesthesia types.
- Results indicated that spinal anesthesia led to more severe pain in the first 24 hours post-surgery and higher prescription analgesic use at 60 days, while patient satisfaction remained comparable across both groups.
Background: After conventional resuscitation from hemorrhagic shock, splanchnic microvessels progressively constrict, leading to impairment of blood flow. This occurs despite restoration and maintenance of central hemodynamics. The authors' recent studies have demonstrated that topical and continuous ex vivo exposure of the gut microvasculature to a glucose-based clinical peritoneal dialysis solution (Delflex), as a technique of direct peritoneal resuscitation (DPR), can prevent these postresuscitation events when initiated simultaneously with conventional resuscitation.
View Article and Find Full Text PDFConventional peritoneal dialysis solution (PDS) relaxes visceral and parietal peritoneal arterioles (microvessels) by unclear mechanisms. The present study was originally designed to investigate the mechanisms of PDS-mediated vascular reactivity. Surprisingly, our preliminary data indicated that PDS induces contraction in large vessels such as the aorta.
View Article and Find Full Text PDFAdequate resuscitation from hemorrhagic shock that preserves hemodynamics is associated with a generalized and progressive intestinal arteriolar vasoconstriction and hypoperfusion coupled with impairment of the endothelium-dependent dilation response. This study was performed to investigate the role of neutrophils on the postresuscitation intestinal arteriolar derangements. Experiments were performed in anesthetized rats 24 h after neutrophil depletion.
View Article and Find Full Text PDFBackground: Alpha-adrenergic agents contract vascular smooth muscle (VSM) and stimulate endothelial release of secondary factors which modulate VSM contraction. Our study examined constrictor prostanoid (cPN) and nitric oxide (NO) as secondary factors which could alter alpha-1 adrenoceptor-mediated contraction during sepsis.
Methods: Sepsis was induced in rats by inoculation of an implanted sponge with Escherichia coli and Bacteroides fragilis.