Publications by authors named "Touhami S"
Sleep apnea that leads to chronic intermittent hypoxia (CIH) is an independent risk factor for advanced, debilitating ischemic proliferative retinopathies, such as diabetic retinopathy (DR) and retinopathy of prematurity (ROP). The underlying mechanisms are unknown. Here we investigated the consequences of CIH on the ischemic retina of the oxygen-induced retinopathy model.
View Article and Find Full Text PDFThe fluocinolone acetonide implant (FAI) is an intravitreal corticosteroid implant designed to have a therapeutic effect lasting up to 3 years. We performed a meta-analysis to investigate the efficacy and safety of the FAI (0.19 mg, releasing at 0.
View Article and Find Full Text PDFPurpose: To report a case highlighting the uncommon presentation of Frosted Branch Angiitis (FBA) in Behçet's Disease (BD), notably in a patient who received a COVID vaccine one month prior to the onset of symptoms. We explore the possible role of vaccination in unmasking BD.
Methods: A comprehensive evaluation of a 45-year-old patient with FBA post-COVID vaccination was undertaken.
Idiopathic Photoreceptoritis: An Unusual Variant of Outer Retinopathy.
Ocul Immunol Inflamm
February 2025
Purpose: To report an unusual case of progressive photoreceptor disruption following a herpetic labial infection.
Method: Case report of a patient with severe idiopathic photoreceptoritis.
Results: A 46-year-old female patient presented with blurred vision and inferior photopsia in her right eye one week after a herpetic labial eruption.
Article Synopsis
- This case report discusses a 35-month-old boy with CBL syndrome who experienced life-threatening Epstein-Barr virus (EBV) infections and rod-cone dystrophy (RCD) that appeared similar to severe panuveitis.
- Genetic testing indicated a pathogenic variant related to CBL syndrome, leading to complications including encephalitis and severe eye inflammation.
- The report emphasizes the importance of considering RCD in CBL syndrome patients with unexplained eye inflammation and suggests using carbonic anhydrase inhibitors as a treatment for cystoid macular edema.
Introduction: We investigated the anatomical and functional results of vitrectomy associated with the peeling of secondary epiretinal membranes (ERM) in patients with retinal vein occlusion (RVO) and determined the prognostic factors of surgical outcomes.
Methods: This retrospective, multicenter, observational study included 50 patients with RVO who underwent vitrectomy with ERM removal between July 2012 and February 2021. Visual acuity (VA) and central macular thickness (CMT) were investigated up to 3 years.
Article Synopsis
- Vitreoretinal lymphoma (VRL) has a poor prognosis due to high relapse rates in the central nervous system, requiring treatments like high-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT).
- A study analyzed 38 adult patients treated with HCT-ASCT for isolated VRL over 11 years, showing that 84% received a thiotepa-based regimen, with some patients experiencing serious side effects.
- Results revealed a significant relapse rate, particularly in the brain, but the strategy showed relatively good median survival rates: 96 months for progression-free survival and 92 months overall.
Viruses belonging to the herpes family group, including HSV (herpes simplex virus) 1 and 2, VZV (varicella zoster virus) and CMV (cytomegalovirus) are the leading causes of necrotizing retinitis. These viral retinal necroses generally manifest in three forms, depending on the patient's immune status: acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN) and CMV retinitis. Although specific, effective drug treatments are available today, early treatment initiation is essential to avoid sight-threatening complications.
View Article and Find Full Text PDFBackground/objectives: The predictive factors of surgical results in uveitic retinal detachment (RD) are lacking. The objective was to study the surgical outcomes and determine the risk factors for surgical failure in rhegmatogenous RD associated with intraocular inflammation (RRDIOI).
Methods: Retrospective series of consecutive eyes with RRDIOI undergoing vitreoretinal surgery between 2012 and 2019 in two French referral centres.
Aims: To compare the safety and efficacy of methotrexate (MTX), mycophenolate mofetil (MMF) and azathioprine (AZA) in non-anterior sarcoidosis-associated uveitis.
Methods: Retrospective study including non-anterior sarcoidosis-associated uveitis according to the revised International Workshop on Ocular Sarcoidosis criteria. The primary outcome was defined as the median time to relapse or occurrence of serious adverse events leading to treatment discontinuation.
Background: Intraocular dexamethasone implant (DEXi) is an efficient treatment for diabetic macular edema (DME). However, it may be unavailable or contraindicated. Triamcinolone acetonide is another corticosteroid that has proved to be safe and effective in treating macular edema complicating various diseases including diabetes.
View Article and Find Full Text PDFPurpose: To evaluate the safety and efficacy of the fluocinolone acetonide implant (FAi, Iluvien Horus pharma, Nice, France) in non-infectious uveitic macular edema (UME) and to approach the predictive factors of treatment response.
Methods: This retrospective, multicenter real-life study included patients with chronic non-infectious UME who received intravitreal FAi after at least two dexamethasone implants (DEXi).
Results: Twenty-six eyes from 22 patients (73.
Background/purpose: Evaluate the performance of a deep learning algorithm for the automated detection and grading of vitritis on ultrawide-field imaging.
Methods: Cross-sectional noninterventional study. Ultrawide-field fundus retinophotographs of uveitis patients were used.
Purpose: To report the clinical features and treatment outcomes in adult Caucasians with ocular toxocariasis (OT) and investigate their prognosis depending on their serological status.
Methods: Retrospective observational cohort study (2016-2021) including consecutive adults with uveitis and positive western blot (WB) in the aqueous humor or vitreous. The presence of serum antibodies was not necessary for inclusion, allowing to compare the outcomes depending on the serological status.
Background And Aim: Ocular sarcoidosis is present in 30-60% of all sarcoidosis patients. Our purpose is to increase awareness of the various presentations of ocular sarcoidosis.
Methods: Short image-based clinical case report.
Article Synopsis
- A new form of retinopathy has been observed in patients with ataxia due to vitamin E deficiency (AVED), which differs from typical retinitis pigmentosa (RP).
- The case series involves two related patients who showed unique retinal patterns characterized by scattered, bright patches that are stable even with vitamin E treatment.
- Researchers suggest that these retinal changes may be due to halted progression of RP in AVED patients who received early vitamin E supplementation.
Purpose: To report a case of Fibroblast Growth Factor Receptor inhibitor (FGFRi) associated retinopathy in a patient treated with Erdafitinib.
Case Report: A patient with a history of non-muscle invasive urothelial carcinoma treated with Erdafitinib developed symptomatic unifocal bilateral serous retinal detachments (SRD) eight weeks after starting this new treatment. Six months after discontinuing the drug, the SRDs resolved and visual acuity recovered to baseline.
Objective: To investigate clinical and spectral-domain optical coherence tomography (SD-OCT) biomarkers correlating with pre-injection visual acuity (VA), post-injection VA, and the likelihood of macular oedema (MO) regression following dexamethasone (DEX) implant injection in non-infectious uveitic (NIU) patients.
Methods: Patient data from Uveitis Services in Milan, Paris, and Berlin were analysed. Eligible participants were NIU patients aged >18 years with MO as the primary indication for DEX treatment.
Article Synopsis
- Systemic drugs can treat retinal issues, but the blood-retina barrier (BRB) limits their effectiveness, prompting research into sonication, which uses ultrasound to temporarily open the BRB.
- In a study with C57/BL6J mice, sonication at 0.15 MPa proved best for safely increasing BRB permeability without harming retinal structure or function.
- This method allows larger molecules (up to 150 kDa) to penetrate the BRB, enhancing drug delivery to the retina without significant side effects.
Article Synopsis
- The condition can manifest as anterior, posterior, or panuveitis, with panuveitis being the most common type, especially in men, and may appear as an initial symptom in 20% of patients or several years later.
- Management focuses on quickly resolving inflammation, preventing future episodes, achieving remission, and protecting vision, with recent advances in biologic therapies showing promise in treatment strategies.
Uveitis in Behçet's disease (BD) is frequent (40% of cases) and is a major cause of morbidity. The age of onset of uveitis is between 20 and 30 years. Ocular involvement includes anterior, posterior, or panuveitis.
View Article and Find Full Text PDFPurpose: To describe a case of T-cell prolymphocytic leukemia (T-PLL) masquerading as viral retinal necrosis (VRN).
Case Presentation: A 75-year-old-man with a history of T-PLL in complete remission complained of an acute vision loss in his right and only eye. Ophthalmic examination demonstrated the presence of anterior chamber cells, mild vitritis, and peripheral retinal whitening with intraretinal hemorrhages evocative of VRN.