Hyaluronic acid/alginate-based biomimetic hydrogel membranes for accelerated diabetic wound repair.

The study aims to develop a new multifunctional biopolymer-based hydrogel membrane dressing by adopting a solvent casting method for the controlled release of cefotaxime sodium at the wound site. Sodium alginate enhances collagen production in the skin, which provides tensile strength to healing tissue. Moreover, the significance of extracellular molecules such as hyaluronic acid in the wound the healing cascade renders these biopolymers an essential ingredient for the fabrication of hydrogel membranes via physical crosslinking (hydrogen bonding).

Silymarin nanocrystals-laden chondroitin sulphate-based thermoreversible hydrogels; A promising approach for bioavailability enhancement.

Hydrogels has gained tremendous interest as a controlled release drug delivery. However, currently it is a big challenge to attain high drug-loading as well as stable and sustained release of hydrophobic drugs. The poor aqueous solubility and low bioavailability of many drugs have driven the need for research in new formulations.

Bioactive and multifunctional keratin-pullulan based hydrogel membranes facilitate re-epithelization in diabetic model.

Hydrogel membrane dressings with multifunctional tunable properties encompassing biocompatibility, anti-bacterial, oxygen permeability, and adequate mechanical strength are highly preferred for wound healing. The present study aimed to develop biopolymer-based hydrogel membranes for the controlled release of therapeutic agent at the wound site. Toward this end we developed Cefotaxime sodium (CTX) loaded keratin (KR)-pullulan (PL) based hydrogel membrane dressings.

Self-crosslinked chitosan/κ-carrageenan-based biomimetic membranes to combat diabetic burn wound infections.

Diabetic wound infection often leads to compromised healing with frequent chances of sepsis, amputation and even death. Traditional patient care emphasized on early debridement and fluid resuscitation followed by intravenous antibiotics therapy. However, compromised vasculature often limit the systemic effect of antibiotics.

Bio-functional hydrogel membranes loaded with chitosan nanoparticles for accelerated wound healing.

Wounds are often recalcitrant to traditional wound dressings and a bioactive and biodegradable wound dressing using hydrogel membranes can be a promising approach for wound healing applications. The present research aimed to design hydrogel membranes based on hyaluronic acid, pullulan and polyvinyl alcohol and loaded with chitosan based cefepime nanoparticles for potential use in cutaneous wound healing. The developed membranes were evaluated using dynamic light scattering, proton nuclear magnetic resonance, Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy.

Bioinspired sodium alginate based thermosensitive hydrogel membranes for accelerated wound healing.

Despite substantial progress made in the development of wound dressings, wound management remains a great challenge, which compels significant burden to the patient and healthcare system. Owing to its intricate pathophysiology particularly, wounds with bacterial burden impose substantial challenges to the conventional wound dressings, and hence, demands development of novel and more efficient wound healing modalities. Therefore, the aim of the present study was to design a novel thermosensitive hydrogel membrane composed of sodium alginate, poloxamer 407, pluronic F-127, and polyvinyl alcohol for accelerated wound healing.