Publications by authors named "Totta Ehret"
Article Synopsis
- Scientists studied a parasite called Eimeria falciformis that infects mice to see how it responds to different immune systems in the mice.
- They looked at the genes (transcriptomes) of both the parasites and the mice to see how they changed depending on the immune strength of the mice.
- The results showed that the parasite seems to follow a “hard wired” program of infection that doesn’t change much based on the host's immune response, suggesting it has evolved a fixed way to infect mice instead of adapting to their defenses.
Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.
Front Cell Infect Microbiol
February 2018
Rodents, in particular , have a long and invaluable history as models for human diseases in biomedical research, although their translational value has been challenged in a number of cases. We provide some examples in which rodents have been suboptimal as models for human biology and discuss confounders which influence experiments and may explain some of the misleading results. Infections of rodents with protozoan parasites are no exception in requiring close consideration upon model choice.
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