Epidermal growth factor receptor/heme oxygenase-1 axis is involved in chemoresistance to cisplatin and pirarubicin in HepG2 cell lines and hepatoblastoma specimens.

Purpose: To investigate the possibility that the antioxidant stress protein Heme oxygenase-1 (HO-1) is involved in the acquisition of chemoresistance in cisplatin and pirarubicin (CITA) therapy.

Methods: Human hepatoblastoma-derived cell line (HepG2) was used to generate a knockdown cell line of HO-1 by small interfering RNA (siRNA). Expression of HO-1, epidermal growth factor receptor (EGFR), Akt, and extracellular signal-regulated kinase1/2 (ERK1/2) was examined by Western blot.

Intra- and intermolecular interaction of anthracene moieties in 7,8-disilabicyclo[3.3.0]octadienyl-bridged bisanthracenes.

Ruthenium-catalyzed dimerization of 9-anthrylarylsilanes afforded air-stable V-shaped bisanthracenes bridged by a 7,8-disilabicyclo[3.3.0]octadiene moiety.

Photocurable ABA triblock copolymer-based ion gels utilizing photodimerization of coumarin.

Herein, we develop a photocurable ABA triblock copolymer-based ion gel, which can be converted from a thermally processable, physically crosslinked ion gel to a thermally and mechanically stable, chemically crosslinked ion gel photoinduced dimerization. The A block consists of a random copolymer of -isopropylacrylamide and a coumarin-containing acrylate monomer, while the B block consists of an ionic liquid-philic poly(ethylene oxide). Due to the upper critical solution temperature-type phase behavior of the A block, the ABA triblock copolymer undergoes gel-to-sol transitions in a hydrophobic ionic liquid as the temperature is increased.

Enhanced Ga2O3-photocatalyzed and photochemical degradation of the Fipronil insecticide by UVC irradiation in mixed aqueous/organic media under an inert atmosphere.

Agrochemicals such as the insecticide Fipronil that bear fluoro groups are generally fat-soluble and nearly insoluble in water, so that their photodegradation in a heterogeneous aqueous gallium oxide dispersion presents some challenges. This article examined the photodegradation of this insecticide by solubilizing it through the addition of organic solvents (EtOH, MeOH, THF, 1,4-dioxane and ethylene glycol) to an aqueous medium and then subjecting the insecticide to 254 nm UVC radiation under photocatalytically inert (Ga2O3/N2) and air-equilibrated (Ga2O3/O2) conditions, as well as photochemically in the absence of Ga2O3 but also under inert and air-equilibrated conditions. Defluorination, dechlorination, desulfonation and denitridation of Fipronil were examined in mixed aqueous/organic media (10, 25 and 50 vol% in organic solvent).

Photoassisted defluorination of fluorinated substrates and pharmaceuticals by a wide bandgap metal oxide in aqueous media.

Persistent fluorinated substances, such as the fluorine-bearing pharmaceutical drugs Fluoxetine (FLX; Prozac) and Fluvoxamine maleate (FOM) together with several other substrates (fluorobenzoic acid and fluoroaliphatic model compounds), were photochemically defluorinated and degraded under UVC illumination in relatively good yields in the presence of a wide band gap metal oxide (β-Ga2O3) in heterogeneous aqueous media. The formation of fluoride ions increased with increasing illumination time under an inert nitrogen atmosphere, the transformation of the aromatic moiety was slower under these conditions, but nonetheless it did occur. The optimal amount of β-Ga2O3 loading for defluorination was 50 mg in aqueous media (0.

Photooxidation of the antidepressant drug Fluoxetine (Prozac®) in aqueous media by hybrid catalytic/ozonation processes.

This article examines the oxidative disposal of Prozac(®) (also known as Fluoxetine, FXT) through several oxidative processes with and without UV irradiation: for example, TiO(2) alone, O(3) alone, and the hybrid methods comprised of O(3) + H(2)O(2) (PEROXONE process), TiO(2) + O(3) and TiO(2) + O(3) + H(2)O(2) at the laboratory scale. Results show a strong pH dependence of the adsorption of FXT on TiO(2) and the crucial role of adsorption in the whole degradation process. Photolysis of FXT is remarkable only under alkaline pH.

Sunlight photo-assisted TiO₂-based pilot plant scale remediation of (simulated) contaminated aquatic sites.

A tubular-type solar photoreactor system powered by commercial solar panels and consisting of six 20-tube modules (Pyrex glass) to mimic a pilot plant scale configuration was designed and constructed to examine the remediation of simulated wastewaters contaminated with various classes of organic pollutants such as endocrine disruptors (e.g. bisphenol A), anionic surfactants (sodium butylnaphthalenesulfonate and sodium dodecyl- benzenesulfonate), herbicides (e.

Polystyrenes with chiral phosphoramide substituents as Lewis base catalysts for asymmetric addition of allyltrichlorosilane: enhancement of catalytic performance by polymer effect.

In the asymmetric addition of allyltrichlorosilane to benzaldehyde, polystyrenes with chiral phosphoramide substituents as Lewis base catalysts showed up to 2.4 times better catalytic activity and 1.4 times higher enantioselectivity than the corresponding low-molecular-weight analogues.