Publications by authors named "Toshiyuki Akama"
Ear Nose Throat J
July 2022
Article Synopsis
- External nasal deformities are common and can result from trauma or developmental issues related to the nasal structure.
- A case presented involved a woman experiencing nasal obstruction due to scarring in the nasal valve area, which was determined not to involve chronic rhinosinusitis or septal deviation.
- She underwent a combined rhinoplasty and Z-plasty surgery, highlighting the need for comprehensive evaluation and possible collaboration with plastic surgeons in treating these conditions.
Ear Nose Throat J
December 2024
Article Synopsis
- Eosinophilic chronic rhinosinusitis (ECRS) leads to severe sinus inflammation, with this study examining the link between bone thickening in the middle turbinate and ECRS recurrence.
- In a group of 246 patients, those with ECRS showed greater bone and mucosal thickening compared to other sinus conditions, indicating more severe inflammation.
- The findings also revealed a strong correlation between the severity of ECRS and osteitis, suggesting that bone thickening may contribute to a higher chance of ECRS coming back after treatment.
Ear Nose Throat J
October 2024
Article Synopsis
- Chronic rhinosinusitis (CRS) often involves mucosal inflammation and may lead to bone thickening; this study focused on the link between unilateral sinus blockage and osteitis.
- The research analyzed 104 patients with unilateral sinus opacification using various scoring systems and found that different sinus conditions presented varying GOSS scores, indicating differences in severity.
- Results showed that mycetoma is more likely than CRS to lead to osteitis, with a significant relationship between sinus inflammation and bone thickening in cases of unilateral sinus issues.
Article Synopsis
- Pancreatic cancer has a high mortality rate largely due to its ability to spread (metastasize), and traditional treatments targeting KRAS have not been effective.
- Researchers found that ARL4C, a small G protein, is often overexpressed in pancreatic cancer and is crucial for cancer cell invasion by localizing to invasive structures.
- ARL4C interacts with IQGAP1 and MMP14, forming a signaling pathway that facilitates the breakdown of the extracellular matrix at invasion sites, and using antisense oligonucleotides against ARL4C showed promise in reducing cancer metastasis in mice.
