Publications by authors named "Toshiya Takamura"

A 39-year-old man presented with a 1-month history of headaches. Imaging revealed a mass with extensive destruction. T2-weighted imaging displayed mixture of low and sponge-like high intensities and also dark area, with FDG PET/CT showing uneven but intense accumulation.

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Article Synopsis
  • - Quiescence is crucial for maintaining neural stem cells (NSCs) in the adult brain, with a focus on their ability to remain inactive over time.
  • - Quiescent NSCs (qNSCs) have enlarged lysosomes that enhance their lysosomal activity, allowing for the rapid degradation of activated EGF receptors compared to proliferating NSCs.
  • - Disruption of lysosomal degradation in qNSCs leads to premature exit from quiescence, while blocking the master regulator TFEB results in increased NSC proliferation, highlighting the role of lysosomal function in regulating NSC maintenance.
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Objectives: To determine the safety and efficacy of the combined regimen of paclitaxel and ifosfamide plus nedaplatin for patients with refractory or relapsed germ cell tumors and impaired renal function.

Methods: Of a total of 68 patients who received paclitaxel, ifosfamide and nedaplatin chemotherapy for germ cell tumors, those with an estimated glomerular filtration rate <60 mL/min/1.73 m before paclitaxel, ifosfamide and nedaplatin treatment were defined as having renal dysfunction.

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In advanced bladder cancer, cisplatin-based chemotherapy has been the standard treatment for many years, but there are many problems in terms of side-effects. Recently, a number of clinical trials using molecular-targeted agents have been conducted, and new therapies are expected that could replace conventional cytotoxic chemotherapy. We herein report that concurrent treatment with fibroblast growth factor receptor (FGFR) inhibitor BGJ398 and the novel histone deacetylase (HDAC) inhibitor OBP-801/YM753/spiruchostatin A synergistically inhibited cell growth and markedly induced apoptosis in high-grade bladder cancer cells.

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The prognosis of muscle-invasive bladder cancer with metastasis is poor. There have been no therapeutic improvements for many years, and an innovative therapy for muscle-invasive bladder cancer has been awaited to replace the conventional cytotoxic chemotherapy. Here, we show a candidate method for the treatment of bladder cancer.

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