Publications by authors named "Toshiya Kobayashi"

Article Synopsis
  • * 41 women took probiotics while 19 served as a control, with milk samples collected at one, two, and three months postpartum.
  • * Significant changes were observed in certain cytokines like IL-1 receptor antagonist, IL-7, and IL-10, suggesting probiotics may influence cytokine levels, but further placebo-controlled studies are needed for conclusive results.
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  • Ticks are blood-feeding ectoparasites that host various microorganisms, including both pathogens and beneficial symbionts that aid in their growth and reproduction.
  • A study in Zambia screened 175 ticks from six different genera for the presence of a specific type of beneficial symbionts, called CLEs, finding that 45.7% were positive.
  • The research indicated a strong evolutionary connection between the ticks and their symbionts, supporting the idea that these CLEs are passed down through generations, but also highlighted the need to explore other potential microorganisms in Zambian ticks.
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Unlabelled: To characterize the milk phospholipids (PLs) profile using phosphorus-31 nuclear magnetic resonance (P-NMR) and to investigate the effect of elevated milk docosahexaenoic acid (DHA) levels on PLs profiles in Japanese mothers.

Methods: Milk samples from eligible patients with high and low DHA from a former cross-sectional study (n = 20; n = 10 for each group) were included. Fifteen milk PLs were analyzed using P-NMR, and the profiles were compared group-wise using Mann-Whitney -test.

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Background: DHA (22:6n-3) is essential for neurodevelopment in children, and its concentration in human breast milk is historically high in Japan. Dietary patterns in Japan might affect the fatty acid (FA) composition among lactating mothers.

Objectives: This study aimed to characterize the composition of milk FAs and to identify any dietary and sociodemographic factors associated with the variability of DHA concentration in breast milk in the Japanese population.

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Article Synopsis
  • A five-year cohort study aims to investigate the relationship between maternal health, nutrition, socioeconomic factors, and the composition of human milk, and how these elements may influence the growth and development of infants and children.
  • The study includes 1,210 Japanese mothers with singleton pregnancies, gathering data from self-administered questionnaires and diet history assessments to analyze various health and lifestyle factors.
  • Human milk samples will be collected every two months in the first year post-birth to analyze macronutrient levels, providing valuable insights into the factors that may affect both milk composition and child development.
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  • A study investigated the safety and effects of probiotic supplementation in lactating mothers with allergies, using specific probiotic strains over a two-month period postpartum.* -
  • Results showed no adverse effects from the probiotics, with a high adherence rate of 91.5%, but changes in immunoglobulin A (IgA) and transforming growth factor-β (TGF-β) levels varied and did not show a clear beneficial impact.* -
  • This research highlights the potential of probiotics in maternal diet for infant allergy prevention, but also points out the inconsistency and controversy surrounding their nutritional and safety benefits.*
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The patient a 75-year-old man who was treated for diabetes and angina pectoris. He relapsed with an angina attack. Coronary angiography revealed three-vessel disease.

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A 45-year-old female was admitted to our hospital due to severe aortic stenosis. Transthoracic and transesophageal echocardiography indicated the aortic valve was bicuspid, but we confirmed that the aortic valve was unicuspid by intraoperative finding. There was 1 open commissure between the left coronary cusp and the noncoronary cusp position.

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The presence of a new electronic interaction, which couples a 4 f-electronic system with a total angular momentum J and a photoexcited cyclic π-conjugated system with an orbital angular momentum L, in the bis(phthalocyaninato)dysprosium single-molecule magnet ([DyPc ] ) is reported. Two π-π* excited states in the visible spectral region of the [DyPc ] complex, which are denoted here as Q and Q , showed significantly different temperature and field dependences of the magnetic circular dichroism (MCD) A-term intensity. This phenomenon not only indicates the presence of a "J-L" interaction, but also that the interaction generates two different preferred orientations of the J-L pair, either parallel (for the Q band) or antiparallel (for the Q band), depending on the excitation energy.

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Primary tumors of the heart are rare. In the literature operations for heart tumors account for 0.3% of all cardiac surgical procedures.

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Dysmenorrhea is a highly prevalent complaint and highly undiagnosed gynecologic condition. Dairy products have a potential in the management of menstrual distress, and bovine lactoferrin can help the subjective dysphoria associated with dysmenorrhea. In the present study, we aimed to investigate the effects of a lactoferrin formulation isolated from cow's milk on menstrual symptoms in volunteers.

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Planktonic metabolism plays crucial roles in Earth's elemental cycles. Chemical speciation as well as elemental stoichiometry is important for advancing our understanding of planktonic roles in biogeochemical cycles. In this study, a multicomponent solid-state nuclear magnetic resonance (NMR) approach is proposed for chemical speciation of cellular components, using several advanced NMR techniques.

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Background: Lactobacillus gasseri SBT2055 (LG2055) has been shown to prevent abdominal adiposity, and suppression of lipid absorption is considered a possible mechanism, detail of which, however, are poorly understood. In the present study, we evaluated the effects of LG2055 on fat hydrolysis by determining pancreatic lipase activity and fat emulsion properties in vitro. We also examined whether LG2055 influences fecal fat excretion in humans.

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Whey proteins or peptides exhibit various actions, including an antioxidant action, an anticancer action, and a protective action against childhood asthma and atopic syndrome. The effects of orally administered whey peptides (WPs) on chronic ultraviolet B (UVB) radiation-induced cutaneous changes, including changes in cutaneous thickness, elasticity, wrinkle formation, etc., have not been examined.

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The iron-lactoferrin complex is a common food ingredient because of its iron-solubilizing capability in the presence of hydrogen carbonate ions. However, it is unclear whether the formation of a stable iron-binding complex is limited to lactoferrin. In this study, we investigated the effects of bovine serum albumin (BSA) on iron solubility and iron-catalyzed lipid oxidation in the presence of hydrogen carbonate ions.

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Unlabelled: The iron-lactoferrin complex (FeLf) is useful for dietary iron supplementation. However, the effects of FeLf on iron-catalyzed off-flavors in lipid-containing food products have not been reported. In this study, we investigated the effects of FeLf on off-flavors development during the production and storage of powdered milk with added fish oil.

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Objectives: Optimum treatment for acute aortic dissection (AAD) with a thrombosed false lumen (thrombosed AAD) remains controversial. We evaluated the outcome of thrombosed AAD according to treatment strategy.

Materials And Methods: We examined 280 patients with AAD, of which 30 had thrombosed AAD.

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Acute pulmonary embolism (APE) is a serious disease. Recently, multidetector-row computed tomography (MDCT) has proven to be valuable in detecting APE and deep vein thrombosis. APE is classified as massive, submassive, and nonmassive.

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Article Synopsis
  • A selective blocking method for the cervical plexus and sympathetic trunk hasn't been established yet, prompting research into neck anatomy.
  • Researchers examined 28 cadavers and conducted CT scans on 2 healthy volunteers to study local anesthetic distribution.
  • Findings revealed the deep cervical plexus's location between specific neck muscles and identified the longus capitis as a suitable landmark for blocking these nerves during procedures.
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A 19-year-old female was referred to our department with a diagnosis of recurrent coarctation of the aorta. She had undergone end-to-side anastomosis of the left subclavian artery with the thoracic aorta at 9 days of age and extra-anatomic subclavian-to-femoral bypass grafting at 15 years of age because of hypertensive crisis. A preoperative 4-slice computed tomography (CT) scan demonstrated recurrent obstruction of the aorta and, unexpectedly, an associated anomaly of bilateral persistent sciatic arteries.

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Background: A specific basic fraction of bovine milk, termed Milk Basic Protein (MBP), has the potential to provide nutritionally important benefits if used as a food ingredient. Although derived from milk, MBP is intended for use as an ingredient in other foods. Cows' milk is a well studied, commonly allergenic food.

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Subclavian artery aneurysms are relatively rare in comparison with other peripheral aneurysms. We report a 65-year-old woman with multiple atherosclerotic aneurysms of the subclavian artery, aortic arch saccular aneurysm and abdominal aortic aneurysm. Two-staged operations by which the infrarenal abdominal aorta was replaced first and median sternotomy extending to the supraclavicular space for the concomitant resection of bilateral subclavian as well as aortic arch aneurysm resulted in good results.

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We describe a case of false aneurysm due to loosening of the anastomotic sutures 5 years after graft replacement for subacute type A aortic dissection. Leakage from the graft was controlled by tightening the suture slack indicating that suture loosening was the cause of the aneurysm. The mechanism was probably the progressive thinning of the edematous swollen aortic wall over the years causing the sutures to loosen.

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To clarify the differential effects of vecuronium on the thumb and on the big toe, train-of-four (TOF) stimuli were applied to the ulnar nerve at the wrist and the tibial nerve at the ankle in anesthetized patients using two acceleration transducers. Ten adult patients, aged 21-55 years, were studied. Anesthesia was induced by an intravenous injection of thiopental, and vecuronium 0.

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