Publications by authors named "Toshirou Yoshioka"
Article Synopsis
- A low birthweight baby was delivered via emergency caesarean section at 33 weeks of gestation due to placental abruption.
- High levels of high-mobility group box-1 (HMGB-1) and interleukin-17 were found in the baby’s umbilical cord blood.
- Immunostaining indicated that HMGB-1 was present in the cells of the umbilical cord, suggesting it was released because of the ischemic conditions caused by the placental abruption.
Background: According to the Consensus 2010 of the International Liaison Committee on Resuscitation (ILCOR), children with moderate to severe hypoxic-ischemic encephalopathy (HIE) should receive brain hypothermic therapy (BHT) after successful resuscitation. Elevated high mobility group box 1 (HMGB1) in the blood at the early stage of brain ischemia-reperfusion injury has been suggested to be involved in the release of various inflammatory cytokines.
Methods: In total, 21 neonates plasma HMGB1 concentration was measured.
Background: High mobility group box 1 (HMGB1), intensively studied in adult patients by several investigators, is suggested to cause potentially fatal conditions such as systemic inflammatory response syndrome (SIRS) and disseminated intravascular coagulation (DIC). However, little is known about the role of this protein in neonates.
Methods: In total, 173 full-term neonates were divided into 4 groups according to mode of delivery: scheduled cesarean section (group E, n=67), unscheduled cesarean section (group ER, n=10), normal delivery (group N, n=64) and other modes of vaginal delivery (group CN, n=32).