Publications by authors named "Toshiro Suga"
Pharmacogenetics
May 2003
Article Synopsis
- - Hypofunction of the NMDA receptor is linked to schizophrenia, as evidenced by substances like phencyclidine causing similar symptoms and mice lacking the NR2A subunit displaying abnormal behavior consistent with the disorder.
- - The study focused on the GRIN2A gene, finding specific genetic variations that showed an association with schizophrenia, particularly a (GT)(n) repeat in its promoter region.
- - Results revealed that longer versions of this repeat were more common in patients and correlated with more severe symptoms, indicating that these genetic variations may increase the risk and severity of schizophrenia by reducing GRIN2A levels in the brain.
