Outcomes, efficacy and risk factors of 27-Gauge vitrectomy for diabetic tractional retinal detachment in Japanese patients.

Purpose: Diabetic retinopathy leads to vision-threatening complications, such as proliferative diabetic retinopathy and tractional retinal detachment (TRD) and is a major global health concern. Despite advancements in vitrectomy techniques, challenges exist in managing postoperative complications and long-term visual acuity. This study aimed to evaluate postoperative outcomes of 27-gauge pars plana vitrectomy (27 g PPV) for diabetic TRD and identify associated risk factors.

Relationship between Image Quality and Reproducibility of Surgical Images in 3D Digital Surgery.

Ophthalmic three-dimensional (3D) digital surgery can reproduce high-definition surgical images; however, 3D digital surgery is limited by recording capacities. We examined the relationship between the minimum image quality required to reproduce surgical images and recording capacity. Patients who underwent simultaneous vitrectomy and cataract surgery by the same surgeon using a 3D digital surgery system at Juntendo University Urayasu Hospital between February and October 2021 were evaluated.

A Case of Nephrotic Syndrome with Bilateral Serous Retinal Detachment and Shallow Anterior Chamber Associated with Ciliary Body Edema.

Nephrotic syndrome is a disease that causes fluid retention in the body due to loss of protein in the blood, which can lead to serous retinal detachment (SRD) in the macula. We report a case of severe SRD in both eyes and angle closure due to ciliary body edema caused by nephrotic syndrome. A 57-year-old man was admitted to the Department of Nephrology in our hospital for a thorough examination of his generalized edema.

Factors Affecting a Short-Term Response to Anti-VEGF Therapy in Diabetic Macular Edema.

Diabetic macular edema (DME) is a common cause of visual impairment in patients with diabetes. Although intravitreal anti-vascular endothelial growth factor (VEGF) injections were efficacious in clinical trials, several patients exhibited a poor response. This study aimed to compare clinical features between patients who were susceptible to intravitreal anti-VEGF injections for DME and those who were not.

Twenty-four-month results of intravitreal aflibercept for macular edema due to branch retinal vein occlusion.

Purpose: To investigate 24-month results of intravitreal aflibercept (IVA) for macular edema due to branch retinal vein occlusion (BRVO-ME).

Study Design: Retrospective study.

Methods: Subjects were treatment-naïve BRVO-ME patients at the Ophthalmology Department of Juntendo University Urayasu Hospital from November 2015 to March 2017 who received IVA treatment for 24 months.

Relationship between Recurrence of Macular Edema Due to Branch Retinal Vein Occlusion and Changes in Choroidal Thickness.

Introduction: The role of vascular endothelial growth factor in macular edema (ME) due to branch retinal vein occlusion (BRVO) by enhancing vascular permeability has been well studied. ME due to BRVO often recurs; however, there has been no report on the relationship between this recurrence and choroidal thickness (CT), considering the high vascularity of the choroid. This study was designed to investigate this relationship.

Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation.

We report our findings in 3 cases of Creutzfeldt-Jakob disease (CJD) with visual disturbances as the initial manifestations. These cases were found to have the Heidenhain variant of CJD. Two cases initially presented with progressively blurred vision and homonymous hemianopia.

Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease.

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by post-transcriptional inhibition of mRNA translation. Dysregulation of miRNAs, including circulating miRNAs, has been reported to play an important role in the development of various diseases, including fibrotic diseases. Aberrant expression of miRNAs in the vitreous humor of vitreoretinal diseased eyes has been reported.

[Effects of vitrectomy as a treatment for proliferative diabetic retinopathy in young patients].

Purpose: To investigate the effects of vitrectomy as a treatment for the proliferative diabetic retinopathy (PDR) in patients under 40 years old.

Methods: Sixty eyes of 37 patients under 40 years old with PDR who had undergone vitrectomy for the first time in Juntendo University Urayasu Hospital were included in this study. Preoperative condition, operation methods, visual acuity after operation and complications both during or after operation, especially neovascular glaucoma (NVG), were reviewed retrospectively.

Intravitreal injection of autologous plasmin enzyme for macular edema associated with branch retinal vein occlusion.

Purpose: To investigate the effects of an intravitreal injection of autologous plasmin enzyme for macular edema associated with a branch retinal vein occlusion (BRVO).

Design: Prospective, interventional case studies.

Methods: Twenty-six eyes of 26 patients (14 men and 12 women) with macular edema resulting from a BRVO were studied.

Two cases of severe degeneration of the macula following vitrectomy with indocyanine green-assisted internal limiting membrane peeling for idiopathic macular hole.

We describe three eyes of two cases of severe degeneration of the macula following vitrectomy with indocyanine green-assisted internal limiting membrane peeling for idiopathic macular hole. We need to remember the possibility of these complications and have to select the procedures that are safest to use for macular hole surgery.

Advantages of using newly developed quartz contact lens with slit illumination from operating microscope.

The purpose of this article is to report the characteristics and advantages of using a newly designed quartz contact lens with slit illumination from an operating microscope for intraocular surgery. The new contact lens is made of quartz. The lens is convex-concave and is used in combination with slit illumination from an operating microscope.

Is transpupillary thermotherapy applicable to the treatment of age-related macular degeneration with pigment epithelial detachment?

The cause of pigment epithelial tears at the edge of a pigment epithelial detachment (PED) following transpupillary thermotherapy (TTT) in eyes with a PED associated with age-related macular degeneration has not been conclusively determined. We have treated two eyes that had a PED with TTT. A pigment epithelial tear developed in one eye but not in the other.

Is transpupillary thermotherapy applicable to the treatment of age-related macular degeneration with pigment epithelial detachment?

The cause of pigment epithelial tears at the edge of a pigment epithelial detachment (PED) following transpupillary thermotherapy in eyes with associated age-related macular degeneration is unclear. We have treated 2 eyes which had a PED with TTT. Our findings suggest pigment epithelial tears are probably related to the shape of the PED and TTT should not applied to a balloon-shaped PED.

Measurement of retinal thickness from three-dimensional images obtained from C scan images from the optical coherence tomography ophthalmoscope.

Background: One of the unique features of the optical coherence tomography (OCT) ophthalmoscope is that it can record C scan images of the retina. The purpose of this study was to determine the best recording time to measure the retinal thickness with the OCT ophthalmoscope. In addition, the accuracy of the measurements was examined by comparing the values obtained by the OCT ophthalmoscope with those obtained with the Stratus OCT Model 3000 (OCT III) assuming that the OCT III gives an accurate measurement of retinal thickness.

In vivo and in vitro feasibility studies of intraocular use of seprafilm to close retinal breaks in bovine and rabbit eyes.

Purpose: Seprafilm, a sodium hyaluronate/carboxymethylcellulose absorbable barrier developed to prevent adhesions after abdominal surgery, adheres well to wet tissue. The authors studied the efficacy of this film for sealing retinal breaks in animals.

Methods: In an in vitro study, a retinal detachment with a hole was created in bovine eyecups after the vitreous gel was removed.

Safety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyes.

Purpose: To investigate the safety of intravitreal microplasmin in rabbits and to confirm previous findings of posterior vitreous detachment (PVD).

Methods: Different doses of microplasmin, from 12.5 microg to 250 microg, in 0.

[Preparation of high-purity and safe autologous plasmin and its clinical application].

Purpose: To report an improved preparation of safer and highly-purified autologous plasmin and to demonstrate its clinical applications.

Methods: Prior to clinical application, animal experiments were carried out. In addition, the activity of plasmin in the vitreous cavity after injection was measured serially.

Retinal vessel changes in a patient with primary systemic nonfamilial amyloidosis.

A case is described that demonstrates retinal vessel changes and suggests the favorable effects of hemodialysis to treat pathology in a patient with primary systemic nonfamilial amyloidosis. A 47-year-old woman diagnosed as having primary systemic nonfamilial amyloidosis at the age of 30 years had linear and dot hemorrhage, venous dilatation, and tortuosity in the right eye. Fluorescein angiography revealed low-density amorphous areas in the walls of dilated veins near the optic disc.

Efficacy of daunorubicin encapsulated in liposome for the treatment of proliferative vitreoretinopathy.

Background And Objective: To investigate the efficacy of daunorubicin encapsulated in liposome as a drug delivery system to treat proliferative vitreoretinopathy (PVR).

Materials And Methods: An experimental PVR model was made in pigmented rabbits by injecting a suspension of conjunctival fibroblasts and platelet-rich plasma into the vitreous cavity. Daunorubicin was encapsulated in newly developed empty liposome by mixing the empty liposome with the drug solution.

Penetrating keratoplasty surgery combined with vitrectomy after failing previous corneal surgery.

Purpose: The preoperative and postoperative factors influencing visual outcome were analyzed in 15 eyes of 15 patients with graft opacity after keratoplasty associated with vitreoretinal disease who underwent combined surgery of fresh corneal retransplantation and vitrectomy.

Materials And Methods: The data obtained consisted of diagnosis, preoperative visual acuity, corneal and vitreoretinal findings at the time of surgery, interval between the first visit and surgery, intraocular pressure before surgery, gonioscopic findings, results of bacterial culture of surgical specimens, surgical procedure for vitrectomy, corneal and vitreous findings after surgery, visual acuity 6 months after surgery, intraocular pressure after surgery, and additional surgical techniques.

Results: The cause of corneal opacity was graft rejection in all patients, who had been treated with high-dose administrations of steroids and cyclosporin.

Multifunction vitreous forceps (maculorrhexis forceps).

We developed novel multifunction vitreous forceps to decrease the frequency of forceps insertion and enable the removal of the internal limiting membrane and other intravitreal membranes for better surgical results. The basic forceps were conventional continuous curvelinear capsulorrhexis (CCC) forceps. The size of the shaft is 23G and its pointed end measures 500 microm in diameter.