Publications by authors named "Toshiro Okuyama"

There seemed to be characteristic risk factors in cirrhotic patients for posthepatectomy complications because these patients have less hepatic reserve as compared with noncirrhotic patients. The aim of the current study was to identify these characteristic risk factors in cirrhotic patients. We performed 419 primary hepatectomies for hepatocellular carcinoma.

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Objective: We clarified the characteristics of the high energy trauma patients that entered the general surgery ward of Fukuoka city hospital (FCH), a 200 bed secondary emergency hospital in Japan.

Patients And Methods: Of the 7,826 total ambulance cases treated from April 2008 to March 2012 in our emergency room, 831 trauma patients who entered our hospital were analyzed. These patients were classified into a non high energy (NHE) and high energy trauma (HE) group based on the mechanisms of injuries.

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Objective: The transition of emergency departments and the current situation of emergency medicine (EM) in Fukuoka City Hospital (FCH) were reviewed.

Methods: The data concerning emergency medicine, such as the transition of intra-hospital emergency systems, were obtained from annual reports published in our hospital. Additionally, the data regarding educational programs for emergency room staff, the number of patients taken to the emergency room by ambulances, the activities regarding the Fukuoka Medical Rally (FMR) and the disaster relief team (DRT) were also reviewed and analyzed.

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Purpose: The prognosis of gastric cancer patients undergoing curability B surgery was retrospectively examined to determine the effectiveness of the administration of oral anti-cancer drugs as postoperative adjuvant chemotherapy.

Methods: This study was based on the outcomes of 86 potentially curative patients who had undergone curability B resection of gastric cancer with or without the subsequent administration of oral 5-fluorouracil analogue. There were 21 patients who underwent surgery alone with no oral anti-cancer agents (group A) and 65 patients who were treated postoperatively, mainly with UFT (Tegafur and uracil; group B).

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Purposes: The purpose of this study was to determine an effective treatment strategy for patients with Stage IV gastric cancer.

Methods: We analyzed the significant prognostic factors in 74 patients who underwent surgery between 1989 and 2005, and were finally determined to have Stage IV gastric cancer. These patients were classified as curability A (n = 0), B (n = 29) and C (n = 45) according to the criteria outlined by Japanese Gastric cancer society.

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Background: We aimed to evaluate the impact of body mass index (BMI) on the short- and long-term outcomes of hepatic resection in patients with hepatocellular carcinoma (HCC).

Methods: We performed 371 hepatic resections in HCC patients whom we categorized into two groups based on BMI: BMI ≥ 25 (n = 77) and BMI <25 (n = 294). We compared surgical outcomes between groups.

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Purpose: We conducted this retrospective study to evaluate the effectiveness of giving oral anti-cancer drugs for 2 years as postoperative adjuvant chemotherapy to gastric cancer patients.

Methods: The subjects were 76 patients with stage II and III gastric cancer, who underwent curative surgery between 1989 and 2008. We divided the 20 years chronologically into the UFT term (1989-2003) and the S-1 term (2004-2008).

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Article Synopsis
  • The study evaluated the effects of aggressive chemotherapy on patients with stage IV gastric cancer, focusing on those treated surgically with potential follow-up chemotherapy.
  • It involved 94 patients, divided into curable and non-curable groups, with treatment phases spanning different years and examining survival outcomes.
  • Results indicated that patients receiving newer chemotherapy drugs showed improved survival rates, particularly in those with residual tumors after surgery, highlighting the potential benefits of innovative treatments for advanced gastric cancer.
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Case Report: We herein report a case of huge gastric carcinoma showing an exophytic growth pattern. The gastric carcinoma measured 160 x 130 mm in size. A radical resection was judged to be impossible preoperatively since the tumor invasion of the pancreas and liver was demonstrated on computed tomography.

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Background And Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate.

Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied.

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Background: The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest by inhibiting the phosphorylation of the cyclin-dependent kinases' complexes and blocking cell cycle progression to the S-phase.

Methods: 195 human gastric cancer specimens were prepared for immunohistochemical staining, using antibodies against p53 and p21.

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