Publications by authors named "Toshiro Io"

Atrial fibrillation (AF) is the most frequent persistent arrhythmia. Many genes have been reported as a genetic background for AF. However, most transcriptome analyses of AF are limited to the atrial samples and have not been evaluated by multiple cardiac regions.

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The heart is a significant organ in mammalian life, and the heartbeat mechanism has been an essential focus of science. However, few studies have focused on species differences. Accordingly, challenges remain in studying genes that have universal functions across species and genes that determine species differences.

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Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a promising strategy for cardiac regeneration in conditions such as ischemic heart disease. Here, we used a modified mRNA (modRNA) gene delivery platform to deliver a cocktail, termed 7G-modRNA, of four cardiac-reprogramming genes-Gata4 (G), Mef2c (M), Tbx5 (T), and Hand2 (H)-together with three reprogramming-helper genes-dominant-negative (DN)-TGFβ, DN-Wnt8a, and acid ceramidase (AC)-to induce CM-like cells. We showed that 7G-modRNA reprogrammed 57% of CM-like cells in vitro.

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Article Synopsis
  • Remimazolam is a new fast-acting IV benzodiazepine that may lead to pharmacological tolerance during long-term use, particularly relevant for withdrawal syndrome in intensive care settings.
  • Current models for studying sedative tolerance are inadequate for remimazolam due to its quick metabolic clearance or unpredictable responses in animals like rodents and dogs.
  • Research using NIBS micropigs showed that tolerance development and recovery times from sedation with remimazolam were less severe compared to midazolam, suggesting remimazolam may be a better option for long-term sedation in humans.
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