Publications by authors named "Toshio Aoyama"
Article Synopsis
- * Researchers studied a C. glabrata strain with a mutation in the CNE1 gene, discovering that disruption causes ER stress and alters cell wall structure by reducing β-1,6-glucan and increasing chitin.
- * The findings revealed a unique ER stress-mediated CWI pathway in C. glabrata that is distinct from related species, suggesting that the calcineurin and ER quality control systems are crucial for maintaining CWI. *
The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses uniquely evolved mechanisms for unfolded protein response mechanisms. Tetracycline-mediated suppression of KRE5, which encodes a predicted UDP-glucose:glycoprotein glucosyltransferase localized in the endoplasmic reticulum, significantly increased cell wall chitin content and decreased cell wall β-1,6-glucan content.
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