Publications by authors named "Toshimoto Seno"
Article Synopsis
- Dandy-Walker syndrome (DWS) often occurs with occipital meningocele (OMC), but only about 40 cases of their association have been reported, including a unique case where the OMC sac grew larger over time.
- A premature baby boy was diagnosed with DWS and a small OMC at birth, which progressively enlarged from 3 cm to 7 cm, leading to moderate hydrocephalus and requiring a surgical intervention involving a cystoperitoneal shunt.
- The study highlights that while most OMCs remain small and stable, understanding the relationship between the occipital bone defect and venous anatomy through CT venography can help in planning effective surgery.
Article Synopsis
- - A 27-year-old woman experienced an ischemic stroke during her first trimester of pregnancy, which turned out to be the first sign of moyamoya disease, a rare vascular disorder.
- - After her stroke symptoms worsened despite treatment, an artificial abortion was performed, leading to an immediate halt in her neurological decline and significant recovery.
- - The case suggests that combining artificial abortion and antithrombotic therapy can effectively manage moyamoya disease-related strokes in pregnant patients by stabilizing blood flow and preventing further neurological damage.
Medulloepithelioma is a rare and highly malignant primitive neuroectodermal tumor that usually occurs in childhood. The diagnosis of this entity required only morphological analysis until the World Health Organization classification of central nervous system (CNS) tumors was revised, and now genetic analysis is necessary. We report a case of medulloepithelioma in the posterior cranial fossa that was diagnosed by both morphological and genetic analyses based on this classification.
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- A 49-year-old female patient successfully underwent a single-stage surgery for a ruptured distal anterior choroidal artery aneurysm, which included aneurysm clipping and bypass surgery.
- The patient's condition before the surgery involved severe headaches and consciousness disturbances due to subarachnoid and intraventricular hemorrhages, confirmed by cerebral angiography.
- Post-surgery results showed no new infarcts, resolution of hemorrhages, and significant recovery, with the patient remaining free of recurrence five years later, demonstrating the approach's effectiveness for acute hemorrhagic cases.
Carmustine wafers are approved for localized treatment of malignant glioma. In this study, overall changes in computed tomography (CT) and magnetic resonance (MR) images of malignant glioma patients treated with carmustine wafer implantation were evaluated. The subjects were 25 patients undergoing craniotomy for malignant glioma resection and carmustine wafer implantation.
View Article and Find Full Text PDFThe secreted protein acidic and rich in cysteine (SPARC) is a secreted glycoprotein that plays an essential role in promoting the motility of invasive tumor cells. In the present study, we investigated the role of SPARC in the motile and invasive activities of human glioma cells by silencing the SPARC gene. Introduction of SPARC-targeted small interfering RNA (siRNA) into glioma cell lines resulted in downregulation of SPARC expression, and significantly suppressed glioma cell migration in vitro.
View Article and Find Full Text PDFMalignant gliomas are characterized by active invasiveness, necrosis, and vascular proliferation. These pathological features have been speculated to be caused by tissue hypoxia. Hypoxia-inducible factor-1 (HIF-1), which is controlled by rapid stabilization of the HIF-1alpha subunit, is a pivotal transcriptional factor in the cellular response to hypoxia.
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