Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning.

Purpose: Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.

Methods: Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed.

Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation.

Disruption of the intestinal microbiota caused by intensive chemotherapy, irradiation and antibiotics can result in development of severe gut graft-versus-host disease and infectious complications, leading to poorer outcomes among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Although the oral cavity is also densely colonized by indigenous microorganisms, the bacterial composition in allo-HSCT recipients remains unclear. We determined the tongue microbiota composition of 45 patients with hematological disorders on the day of transplantation and compared them to 164 community-dwelling adults.

A Cross-Sectional Study of Age-Related Changes in Oral Function in Healthy Japanese Individuals.

Background: Oral function deterioration is related to a variety of factors, including aging, decline in activities of daily living, malnutrition, and cognitive decline. This cross-sectional study examined the effects of aging on oral function in healthy individuals.

Methods: A retrospective study was conducted on 175 healthy, independent patients aged 40-89 years, without dementia and with ≥20 teeth, who visited a local dental clinic in Japan.

Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants.

Background/purpose: The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed.

Materials And Methods: The medical charts of these patients were investigated.

Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat.

We investigated actions of uridine 5'-triphosphate (UTP) in rat aorta, cerebral and mesenteric arteries, and their single myocytes. UTP (≥10 µM) elicited an inward-rectifying current strongly reminiscent of activation of P2X(1) receptor, and a similar current was also induced by α,β-methylene adenosine 5'-triphosphate (ATP) (≥100 nM). UTP desensitized α,β-methylene ATP-evoked current, and vice versa.

[Postoperative bleeding after tooth extractions in patients controlled with warfarin--a clinico-statistical study on the factors influencing postoperative bleeding].

There are many reports about tooth extractions of patients taking warfarin, however PT-INR level is used to examine the postoperative bleeding in patients. To investigate other factors, postoperative bleeding, age, gender, PT-INR level, combined use of anti-platelet drugs, conditions of extracted tooth, a number of tooth extractions at a treatment, methods of management for warfarin therapy, degree of the alveolar bone loss and size of radiolucency of apical region were examined in this study. To apply Mann-Whitney U-test and chi2-test, ninety-three patients (38 male and 55 female) who took warfarin and visited our clinic for tooth extractions from April 1994 to November 2002 were classified into 2 groups: One group showed hemostasis by the next day (77 patients), the other showed the continuous bleeding after the next day (16 patients).